System for selective activation of a nerve trunk using a transvascular reshaping lead

• US 7,617,003 B2
• Filed: 05/16/2005
• Issued: 11/10/2009
• Est. Priority Date: 05/16/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Moffitt, Julia, Scheiner, Avram, Caparso, Anthony
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US11/130,022
• Publication Number:
  US 20060259107A1
• Time in Patent Office: 1,639 Days
• Field of Search: 607/115, 607/116, 607/117, 607/119, 607/122, 607/126
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/057 Anchoring means; Means for fixing the head inside the heart
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.

Claims

1. An electrical lead, comprising:

a proximal portion adapted to connect to an implantable medical device;

an expandable portion adapted to be chronically implanted in a blood vessel proximate a nerve trunk, the expandable portion further adapted to be expanded to asymmetrically expand the blood vessel against the nerve trunk to reshape the nerve trunk and spread nerve bundles of the nerve trunk; and

a plurality of electrodes along the expandable portion of the lead;

wherein an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk.

2. The electrical lead of claim 1, wherein the expandable portion includes an oval shape.

3. The electrical lead of claim 1, wherein the expandable portion includes a stent.

4. The electrical lead of claim 1, wherein the expandable portion includes a bias lead.

5. The electrical lead of claim 1, wherein the expandable portion is configured to be implanted in a blood vessel proximate a peripheral nerve trunk.

6. The electrical lead of claim 5, wherein the expandable portion is configured to be implanted in a blood vessel proximate a sympathetic nerve.

7. The electrical lead of claim 5 wherein the expandable portion is configured to be implanted in a blood vessel proximate a parasympathetic nerve.

8. The electrical lead of claim 5, wherein the expandable portion is configured to be implanted in a blood vessel proximate a vagal cardiac nerve.

9. The electrical lead of claim 8, wherein the expandable portion is configured to be implanted in the internal jugular vein within a carotid sheath.

10. The electrical lead of claim 5, wherein the expandable portion is adapted to be implanted in a blood vessel proximate a femoral nerve trunk.

11. The electrical lead of claim 5, wherein the expandable portion is adapted to be implanted in a blood vessel proximate an ulna nerve trunk.

12. A system, comprising:

a lead having a proximal portion and an expandable portion, the expandable portion adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and the expandable portion further adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk;

a plurality of electrodes along the expandable portion of the lead; and

an implantable device coupled to the proximal portion of the lead, the implantable device including;

a neural stimulator; and

a controller to communicate with the neural stimulator, the controller being adapted to deliver an electrical signal to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk.

13. The system of claim 12, wherein the lead includes an oval shaped lead.

14. The system of claim 12, wherein the lead includes a stent.

15. The system of claim 12, wherein the lead includes a bias lead.

16. The system of claim 12, wherein the lead is configured for implantation proximate a vagal cardiac nerve.

17. The system of claim 16, wherein the lead is implantable in a blood vessel proximate a vagal cardiac nerve and the instructions are operable on by the controller to deliver a programmable electric pulse therapy to transvascularly stimulate the vagal cardiac nerve to inhibit cardiac remodeling.

18. A system, comprising:

means for generating a neural stimulation signal; and

means for providing the neural stimulation signal to a nerve bundle, including means for chronically implanting a lead within a blood vessel proximate a nerve trunk, wherein the lead is adapted to be expanded to asymmetrically expand the blood vessel against the nerve trunk to reshape the nerve trunk and spread nerve bundles of the nerve trunk.

19. The system of claim 18, wherein the means for providing the neural stimulation includes a means for delivering neural stimulation to selectively activate the nerve trunk.

20. The system of claim 18, wherein the means for providing the neural stimulation includes a plurality of electrodes along the lead.

21. The system of claim 20, wherein the lead is adapted to reshape the nerve trunk to bring neural fibers of interest closer to the one of the plurality of electrodes, reducing a threshold bias for stimulating the nerve trunk.

22. The system of claim 18, wherein the lead is adapted to reshape the nerve trunk to increase available area for electrical contact placement.

23. The system of claim 18, wherein the lead is configured for implantation proximate a vagal cardiac nerve.

24. A method, comprising:

reshaping a blood vessel proximate a nerve trunk to an elongated shape thereby reshaping the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk, wherein reshaping the blood vessel includes expanding an expandable portion of a lead adapted to be chronically implanted in the blood vessel; and

delivering an electrical signal from an implanted medical device to an electrode positioned at the expandable portion of the lead to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk.

25. The method of claim 24, wherein delivering an electrical signal includes delivering neural stimulation to selectively activate small amounts of axons within the nerve trunk.

26. The method of claim 24, wherein delivering an electrical signal includes delivering neural stimulation to selectively activate afferent axons within the nerve bundle.

27. The method of claim 24, wherein delivering an electrical signal includes delivering neural stimulation to selectively activate efferent axons within the nerve bundle.

28. The method of claim 24, wherein expanding an expandable portion of a lead to reshape the nerve trunk to an elongated shape includes bringing neural fibers of interest closer to the one of the plurality of electrodes, reducing a threshold bias for stimulating the nerve trunk.

29. The method of claim 24, wherein expanding an expandable portion of a lead to reshape the nerve trunk to an elongated shape includes increasing available area for electrical contact placement.

30. The method of claim 24, wherein expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk includes expanding an expandable portion of a lead, adapted to be chronically implanted in a internal jugular vein proximate a vagal nerve trunk within a carotid sheath.

31. The method of claim 30, wherein delivering an electrical signal includes delivering neural stimulation to selectively activate the vagal nerve trunk.

32. The method of claim 30, wherein expanding an expandable portion of a lead to reshape the vagal nerve trunk to an elongated shape includes bringing vagal neural fibers of interest closer to the one of the plurality of electrodes, reducing a threshold bias for stimulating the vagal nerve trunk.

33. The method of claim 30, wherein expanding an expandable portion of a lead to reshape the vagal nerve trunk to an elongated shape includes increasing available area for electrical contact placement.

34. The method of claim 24, wherein expanding an expandable portion of a lead to reshape the blood vessel includes asymmetrically expanding the expandable portion of the lead.

35. The method of claim 24, further comprising:

sensing electrical signals from the nerve trunk using the lead.

36. A method, comprising:

expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk, to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk; and

delivering an electrical signal from an implanted medical device to an electrode positioned at the expandable portion of the lead to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk,

wherein delivering an electrical signal includes delivering neural stimulation to selectively activate small amounts of axons within the nerve trunk.

37. A method, comprising:

expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk, to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk; and

delivering an electrical signal from an implanted medical device to an electrode positioned at the expandable portion of the lead to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk,

wherein delivering an electrical signal includes delivering neural stimulation to selectively activate afferent axons within the nerve bundle.

38. A method, comprising:

expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk, to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk; and

delivering an electrical signal from an implanted medical device to an electrode positioned at the expandable portion of the lead to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk,

wherein delivering an electrical signal includes delivering neural stimulation to selectively activate efferent axons within the nerve bundle.

39. A method, comprising:

expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk, to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk; and

delivering an electrical signal from an implanted medical device to an electrode positioned at the expandable portion of the lead to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk,

wherein expanding an expandable portion of a lead, adapted to be chronically implanted in a blood vessel proximate a nerve trunk includes expanding an expandable portion of a lead, adapted to be chronically implanted in a internal jugular vein proximate a vagal nerve trunk within a carotid sheath.

40. The method of claim 39, wherein delivering an electrical signal includes delivering neural stimulation to selectively activate the vagal nerve trunk.

41. The method of claim 39, wherein expanding an expandable portion of a lead to reshape the vagal nerve trunk to an elongated shape includes bringing vagal neural fibers of interest closer to the one of the plurality of electrodes, reducing a threshold bias for stimulating the vagal nerve trunk.

42. The method of claim 39, wherein expanding an expandable portion of a lead to reshape the vagal nerve trunk to an elongated shape includes increasing available area for electrical contact placement.