Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
First Claim
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1. An apparatus for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
- a gas bottle having nitrogen dioxide and capable of providing a flow of gaseous nitrogen dioxide; and
a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the flow from the gas bottle and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature,wherein the receptacle is configured to attach to the gas bottle.
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Abstract
A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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Citations
28 Claims
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1. An apparatus for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
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a gas bottle having nitrogen dioxide and capable of providing a flow of gaseous nitrogen dioxide; and a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the flow from the gas bottle and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature, wherein the receptacle is configured to attach to the gas bottle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 28)
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15. An apparatus for calibration comprising:
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a gas bottle having nitrogen dioxide and capable of providing diffusing gaseous nitrogen dioxide into an air flow; a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the air flow from the gas bottle and fluidly communicate the air flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature; and a device to control whether the air flow is directed through the receptacle before the air flow is provided to an instrument being calibrated, wherein the receptacle is configured to attach to the gas bottle. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification