Manipulation of cytokine levels using CD83 gene products
First Claim
Patent Images
1. An antibody that can bind to a CD83 polypeptide of SEQ ID NO:
- 9, wherein activated CD4+ T-cells produce lower levels of interleukin-4 when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises a light chain sequence set forth in SEQ ID NO;
58.
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Abstract
The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system.
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Citations
35 Claims
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1. An antibody that can bind to a CD83 polypeptide of SEQ ID NO:
- 9, wherein activated CD4+ T-cells produce lower levels of interleukin-4 when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises a light chain sequence set forth in SEQ ID NO;
58. - View Dependent Claims (3, 9, 10, 11, 12, 13)
- 9, wherein activated CD4+ T-cells produce lower levels of interleukin-4 when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises a light chain sequence set forth in SEQ ID NO;
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2. An antibody that can bind to a CD83 polypeptide of SEQ ID NO:
- 9, wherein CD4+ T-cell proliferation is decreased when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises a light chain sequence set forth in SEQ ID NO;
58. - View Dependent Claims (14, 15, 16, 17)
- 9, wherein CD4+ T-cell proliferation is decreased when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises a light chain sequence set forth in SEQ ID NO;
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4. An antibody that can bind to a CD83 polypeptide of SEQ ID NO:
- 9, wherein activated CD4+ T-cells produce lower levels of interleukin-4 when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
60. - View Dependent Claims (18, 19, 20, 21, 22)
- 9, wherein activated CD4+ T-cells produce lower levels of interleukin-4 when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
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5. An antibody that can bind to a CD83 polypeptide of SEQ ID NO:
- 9, wherein CD4+ T-cell proliferation is decreased when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
60. - View Dependent Claims (23, 24, 25, 26, 27)
- 9, wherein CD4+ T-cell proliferation is decreased when said T-cells are contacted with the antibody, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
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6. An antibody that modulates the activity or expression of a CD83 polypeptide of SEQ ID NO:
- 9, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
60. - View Dependent Claims (7, 8, 28, 29, 30)
- 9, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the heavy chain sequence set forth in SEQ ID NO;
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31. An antibody that modulates the activity or expression of a CD83 polypeptide of SEQ ID NO:
- 9, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the light chain sequence set forth in SEQ ID NO;
58. - View Dependent Claims (32, 33, 34, 35)
- 9, wherein said antibody comprises a light chain and a heavy chain, and wherein the antibody comprises the light chain sequence set forth in SEQ ID NO;
Specification