Inositol pyrophosphates, and methods of use thereof
First Claim
Patent Images
1. A method of enhancing oxygen delivery to a tissue or organ of a mammal, comprising the step of administering to a mammal a therapeutically effective amount of a compound represented by structure I:
5 Assignments
0 Petitions
Accused Products
Abstract
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
-
Citations
19 Claims
- 1. A method of enhancing oxygen delivery to a tissue or organ of a mammal, comprising the step of administering to a mammal a therapeutically effective amount of a compound represented by structure I:
-
3. A method of enhancing oxygen delivery to a tissue or organ of a mammal, comprising the step of administering to a mammal red blood cells previously treated with a compound represented by structure I:
- 4. A method of treating a mammal afflicted with a cardiovascular disease, comprising the step of administering to said mammal a therapeutically effective amount of a compound represented by structure I:
- 6. A method of treating a mammal afflicted with a cardiovascular disease comprising the step of administering to said mammal red blood cells previously treated with a compound represented by structure I:
-
7. A method of improving the oxygen delivering capability of mammalian blood, comprising the step of adding to a volume of mammalian blood a compound represented by structure I:
-
8. A method of incorporating a therapeutically useful substance into mammalian red blood cells, comprising the step of treating a sample of mammalian red blood cells with a compound represented by structure I:
Specification