Cranial nerve stimulation to treat eating disorders

• US 7,620,455 B2
• Filed: 10/25/2005
• Issued: 11/17/2009
• Est. Priority Date: 10/25/2005
• Status: Active Grant

• Current Assignee: LivaNova USA, Inc. (LivaNova Plc)
• Original Assignee: Cyberonics, Inc
• Inventors: Maschino, Steven E.
• Primary Examiner(s): Bockelman; Mark W
• Assistant Examiner(s): Bertram; Eric D.
• Application Number:
  US11/258,764
• Publication Number:
  US 20070093870A1
• Time in Patent Office: 1,484 Days
• Field of Search: 607/40
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36085 Eating disorders or obesity

Abstract

Methods and systems of treating a patient having an eating disorder involving coupling at least one electrode to at least one cranial nerve of the patient, implanting a sensory stimulation device in the patient, applying a sensory stimulus to the patient using the sensory stimulation device, detecting the patient'"'"'s response to the sensory stimulus, and applying an electrical signal to the cranial nerve using the electrode after detecting the response to treat the eating disorder. The methods and systems are effective in treating bulimia.

Claims

1. A method of treating a patient having an eating disorder using an implantable medical device, comprising:

applying a stimulus to said patient using said implantable medical device;

detecting at least one response selected from the group consisting of a refractory period, a signal latency, a synaptic latency, a synaptic jitter, and a conduction delay resulting from said stimulus;

comparing said at least one response resulting from said stimulus to at least one response associated with a predetermined threshold to detect a change in said response; and

applying an electrical signal to a portion of a vagus nerve of said patient based upon said change in said response, for treating an eating disorder of the patient.

2. The method of claim 1, wherein detecting said refractory period comprises detecting a time period after an action potential is induced in a nerve of the patient.

3. The method of claim 1, wherein detecting said conduction delay comprises measuring a time period between the neuronal transmission of an action potential in a nerve of the patient and the arrival of a resultant signal at a target location corresponding to said neuronal transmission.

4. The method of claim 1, wherein detecting said signal latency comprises detecting a time period of apparent inactivity between the time a stimulus signal is applied and the time a response occurs.

5. The method of claim 4, wherein detecting said synaptic jitter comprises detecting variability in said latency of neuronal transmission.

6. The method of claim 1, wherein detecting said synaptic latency comprises detecting a time period between delivery of a stimulus signal and the arrival of the synaptic event at a target location.

7. The method of claim 1, wherein said stimulus is selected from the group consisting of a noxious stimulus, a pain stimulus, a temperature stimulus, and a discomfort stimulus.