Processes and apparatus for extraction of active substances and enriched extracts from natural products

• US 7,622,140 B2
• Filed: 05/07/2002
• Issued: 11/24/2009
• Est. Priority Date: 05/04/2001
• Status: Expired due to Term

• Current Assignee: GW Pharmaceuticals Limited (Jazz Pharmaceuticals Plc)
• Original Assignee: GW Pharmaceuticals Limited (Jazz Pharmaceuticals Plc)
• Inventors: Downs, David, Pate, David, Guy, Geoffrey, Whittle, Brian
• Primary Examiner(s): HOFFMAN, SUSAN COE
• Application Number:
  US10/476,718
• Publication Number:
  US 20040147767A1
• Time in Patent Office: 2,758 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: B01D 11/0242 in towers, e.g. comprising contacting elements
• CPC Class Codes: B01D 11/0273 in rotating drums
• CPC Class Codes: B01D 11/028 Flow sheets
• CPC Class Codes: B01D 11/0288 Applications, solvents
• CPC Class Codes: B01D 2011/007 Extraction using a solvent in the gas phase

Abstract

Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

Claims

1. A process for selectively preparing a cannabinoid-containing extract from cannabis plant material or a solvent extract thereof loaded onto an inert matrix material, comprising:

contacting the cannabis plant material or solvent extract with a heated gas at a temperature which is greater than 100°

C. and sufficient to volatilise at least one cannabinoid but does not cause pyrolysis of the cannabis plant material or solvent extract thereby volatilising the at least one cannabinoid to form a vapour, wherein the heated gas is one of a reducing gas and a non-oxidising gas;

wherein the temperature to which the gas is heated is a temperature at which the target cannabinoid will volatilise condensing the vapour; and

collecting the condensed vapour to form a selective cannabinoid-containing extract.

2. A process according to claim 1 wherein the cannabinoid-containing extract is substantially free of ballast.

3. A process according to claim 2 wherein the cannabinoid-containing extract is substantially free of fats, waxes, carbohydrates, proteins and sugars.

4. A process according to claim 1 wherein the cannabinoid-containing extract is substantially free of terpenes.

5. A process according to claim 1 wherein the cannabinoid-containing extract is substantially free from waxes, sterols and other lipid soluble components of solvent extracts.

6. A process according to claim 1 wherein the cannabinoid-containing extract contains THC.

7. A process according to claim 1 wherein the cannabinoid-containing extract contains CBD.

8. A process according to claim 1 wherein the heated gas is forced upwardly through the cannabis plant material, which is retained in a perforated container, or the solvent extract.

9. A process according to claim 1 wherein the heated gas is blown onto the cannabis plant material or solvent extract.

10. A process according to claim 1 wherein the cannabis plant material or solvent extract is subjected to continuous agitation.

11. A process according to claim 10 wherein the continuous agitation is effected by subjecting the cannabis plant material or solvent extract to a rotary action.

12. A process according to claim 1 wherein the cannabis plant material or solvent extract is presented to the heated gas in a counter-current manner.

13. A process according to claim 1 wherein the cannabis plant material is wet plant material and the process further comprises a pre-treatment step in which the cannabis plant material is contacted with a heated gas at a temperature which is sufficient to dry the cannabis plant material.

14. A process according to claim 1 wherein the reducing gas is one of nitrogen, carbon dioxide, helium and argon.

15. A process according to claim 1 wherein the non-oxidising gas is dry steam.

16. A process according to claim 1 wherein the reducing gas is steam to which has been added sodium metabisulphite in a quantity sufficient to produce 10-500 parts of sulphur dioxide per million parts of the cannabis plant material or solvent extract.

17. A process according to claim 1 wherein the vapour is treated to remove particulate matter prior to the condensing step.

18. A process according to claim 1 wherein the temperature of the heated gas used to volatilise the cannabinoids is selected to effect decarboxylation of cannabinoid acids present to free cannabinoids and to volatilise the free cannabinoids.

19. A process according to claim 18 wherein the temperature of the heated gas used to volatilise the cannabinoids is in the range of from 105°

C. to 450°

C.

20. A process according to claim 19 wherein the temperature of the heated gas used to volatilise the cannabinoids is in the range of from 105°

C. to 225°

C.

21. A process according to claim 20 wherein the cannabis plant material or solvent extract is a high CBD cannabis plant or a solvent extract thereof and the temperature of the heated gas used to volatilise the cannabinoids is in the range of from 120°

C. to 140°

C.

22. A process according to claim 20 wherein the cannabis plant material or solvent extract is a high THC cannabis plant or a solvent extract thereof and the temperature of the heated gas used to volatilise the cannabinoids is in the range of from 105°

C. to 120°

C.

23. A process according to claim 1 wherein the temperature of the heated gas used to volatilise the at least one cannabinoid of the natural product is varied in at least two discrete steps.

24. A process according to claim 23 wherein the step of contacting comprises contacting the cannabis plant material or solvent extract with a heated gas at a first temperature and contacting the cannabis plant material or solvent extract with a heated gas at a second temperature which is greater than the first temperature, the second temperature being greater than 100°

C. and sufficient to volatilise the at least one or more cannabinoids but does not cause pyrolysis of the cannabis plant material or solvent extract, and wherein the condensing step condenses vapour formed at least one of the first and second temperatures.

25. A process according to claim 24 wherein vapours formed at the first and the second temperatures are condensed and collected in separate fractions.

26. A process according to claim 24 wherein the cannabis plant material or solvent extract is a high CBD cannabis plant or solvent extract thereof, the first temperature is in the range of from 125°

C. to 150°

C., and the second temperature is in the range of from 175°

C. to 200°

C.

27. A process according to claim 24 wherein the cannabis plant material or solvent extract is a high THC cannabis plant or extract thereof, the first temperature is in the range of from 60°

C. to 90°

C., and the second temperature is in the range of from 130°

C. to 175°

C.

28. A cannabinoid-containing extract which is substantially free of volatile terpenes, comprising:

about 98% tetrahydrocannabinol (THC);

about 2.5% cannabidiol (CBD);

about 0.5% cannabinol (CBN); and

only trace amounts of tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and ballast.