Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
First Claim
1. A method of treating cognitive impairment associated with Alzheimer'"'"'s disease, schizophrenia or related idiopathic psychoses, Huntington'"'"'s disease, Tourette'"'"'s syndrome, anxiety, affective disorders, drug-induced psychoses, psychoses secondary to neurodegenerative disorders, major depression, bipolar disorder, depression with psychotic features, or sleep disorders, comprising administering to a subject exhibiting one or more symptoms of cognitive impairment a therapeutically effective amount of a compound of Formula I:
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Abstract
Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.
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Citations
26 Claims
- 1. A method of treating cognitive impairment associated with Alzheimer'"'"'s disease, schizophrenia or related idiopathic psychoses, Huntington'"'"'s disease, Tourette'"'"'s syndrome, anxiety, affective disorders, drug-induced psychoses, psychoses secondary to neurodegenerative disorders, major depression, bipolar disorder, depression with psychotic features, or sleep disorders, comprising administering to a subject exhibiting one or more symptoms of cognitive impairment a therapeutically effective amount of a compound of Formula I:
Specification