Heteroaryl sulfonamides and CCR2

• US 7,622,583 B2
• Filed: 07/14/2006
• Issued: 11/24/2009
• Est. Priority Date: 01/14/2005
• Status: Active Grant

• Current Assignee: ChemoCentryx, Inc. (Amgen Inc.)
• Original Assignee: ChemoCentryx, Inc. (Amgen Inc.)
• Inventors: Hansen, Derek, Zeng, Yibin, Wei, Zheng, Punna, Sreenivas, Chen, Wei, Ungashe, Solomon, Jin, Jeff, Basak, Arindrajit, Charvat, Trevor T., Dairaghi, Daniel, Wright, John J., Pennell, Andrew M. K., Moore, Jimmie
• Primary Examiner(s): Desai; Rita J
• Assistant Examiner(s): Mabry; John
• Application Number:
  US11/486,974
• Publication Number:
  US 20070037794A1
• Time in Patent Office: 1,229 Days
• Field of Search: 546/255
• US Class Current: 546/113
• CPC Class Codes: A61K 31/437 the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: C07C 311/21 having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07D 213/75 Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• CPC Class Codes: C07D 241/22 Benzenesulfonamido pyrazines
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 401/10 linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 407/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 498/04 Ortho-condensed systems

Abstract

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

Claims

1. A compound of the formula (XCVI), or a salt thereof:

4. The compound of claim 1, or a salt thereof, wherein X^b is chloro, and X^c is CF₃;

Y^b is methyl and Y^a is hydrogen; and

R⁴⁷ is hydrogen.

5. A composition comprising a pharmaceutically acceptable carrier and a compound of claim 1.

2. A compound of formula XCVI, or a salt thereof:

3. The compound of claim 2, or a salt thereof, wherein X^b is chloro, and X^c is CF₃;

Y^b is methyl; and

Y^a is hydrogen.