Stimulus regimens for cardiovascular reflex control
First Claim
1. A method of controlling a baroreflex activation device for the treatment of hypertension, the method comprising:
- implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors, the baroreflex activation device including at least one electrode configured to deliver therapy to the one or more baroreceptors based on a control signal;
providing a controller coupled to the baroreflex activation device; and
using the controller to generate the control signal based on a therapy interval defined by a plurality of burst intervals each defined by a series of electrical pulses and including a first burst portion and a second burst portion each having a burst average power defined by a number of electrical pulses delivered over a period less than or equal to that burst portion, wherein the therapy interval includes a first therapy portion and a second therapy portion each having a therapy average power defined by a number of electrical pulses delivered over a period at least equal to a plurality of burst intervals, wherein the burst average power of the first burst portion is different than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is different than the therapy average power of the second therapy portion.
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Accused Products
Abstract
Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
350 Citations
20 Claims
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1. A method of controlling a baroreflex activation device for the treatment of hypertension, the method comprising:
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implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors, the baroreflex activation device including at least one electrode configured to deliver therapy to the one or more baroreceptors based on a control signal; providing a controller coupled to the baroreflex activation device; and using the controller to generate the control signal based on a therapy interval defined by a plurality of burst intervals each defined by a series of electrical pulses and including a first burst portion and a second burst portion each having a burst average power defined by a number of electrical pulses delivered over a period less than or equal to that burst portion, wherein the therapy interval includes a first therapy portion and a second therapy portion each having a therapy average power defined by a number of electrical pulses delivered over a period at least equal to a plurality of burst intervals, wherein the burst average power of the first burst portion is different than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is different than the therapy average power of the second therapy portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method, comprising:
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providing a baroreflex activation device including at least one electrode configured to deliver therapy to one or more baroreceptors based on a control signal; providing a controller coupled to the baroreflex activation device; and providing instructions for controlling the baroreflex activation device for the treatment of hypertension, the instructions comprising; implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors; generating the control signal with the controller based on a therapy interval defined by a plurality of burst intervals each defined by a series of electrical pulses and including a first burst portion and a second burst portion each having a burst average power defined by a number of electrical pulses delivered over a period less than or equal to that burst portion, wherein the therapy interval includes a first therapy portion and a second therapy portion each having a therapy average power defined by a number of electrical pulses delivered over a period at least equal to a plurality of burst intervals, wherein the burst average power of the first burst portion is different than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is different than the therapy average power of the second therapy portion.
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Specification