Modulation of the brain to affect psychiatric disorders

• US 7,623,927 B2
• Filed: 12/24/2002
• Issued: 11/24/2009
• Est. Priority Date: 12/24/2001
• Status: Expired due to Fees

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Rezai, Ali R.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US10/329,285
• Publication Number:
  US 20030181954A1
• Time in Patent Office: 2,527 Days
• Field of Search: 607/45, 607/2, 607/3, 600/378, 600/544
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A method for treating neurological conditions by proper placement of a probe and sensing, stimulating or both, in pre-determined areas of the brain, especially the intralaminar nuclei (ILN″). Moreover, stimulation is controlled and offered when certain conditions within the area of interest are detected. Stimulation and sensing include biological, electrical, chemical or combinations thereof.

Claims

1. A method of treating autism in a patient in need thereof, comprising:

placing a device in contact with a target site in the brain of a patient having autism or;

selecting parameters to modulate the brain to treat the autism; and

operating the device based on the selected parameters to modulate the brain to treat the autism, wherein the target site is not a dural venous sinus or dura adjacent to the dural venous sinus.

2. The method of claim 1, wherein the modulation is electrical.

3. The method of claim 2, wherein the device is an electrode assembly.

4. The method of claim 1, wherein the modulation is chemical.

5. The method of claim 4, wherein the device is a sustained-release matrix.

6. The method of claim 1, further comprising sensing activity in a specific area of the brain associated with the autism, and wherein the device is operated in response to the sensed activity.

7. The method of claim 6, wherein the activity being sensed is electrical activity.

8. The method of claim 6, wherein the activity being sensed is chemical activity.

9. The method of claim 6, wherein said specific area is selected from the group consisting of:

pre-frontal cortex;

orbitofrontal cortex;

anterior limb of the internal capsule;

nucleus accumbens;

inferior, middle, or superior frontal gyms;

medial frontal gyms;

ventral striatum;

ventral pallidum;

anterior nucleus of the thalamus;

dorsomedial nucleus of the thalamus;

intralaminar thalamic nuclei;

cingulate cortex;

amygdala;

hippocampus;

parahippocampal gyms;

pre-cuneus gyms;

anterior medial pallidum;

mammilary bodies;

lateral hypothalamus;

locus cemleus;

dorsal raphe nucleus;

ventra tegmentum;

substantia nigra pars compacta or reticulata;

dorsal surface of the cerebellar hemisphere; and

anterior lateral surface of the cerebellar hemispheres.

10. The method of claim 6, wherein said specific area is selected from the group consisting of:

ventral striatum, ventral pallidum, anterior medial pallidum, hippocampus, parahippocampal gyms, pre-cuneus gyms, lateral hypothalamus, ventral tegmentum, dorsal surface of the cerebellar hemispheres, and anterior lateral surface of cerebellar hemispheres.

11. The method of claim 6, wherein the specific area is selected from the group consisting of:

ventral pallidum and anterior medial pallidum.

12. The method of claim 6, wherein the sensing occurs epidurally, subdurally, or on the scalp.

13. The method of claim 1, wherein the target site is an intralaminar nuclei of the brain.

14. The method of claim 1, wherein the target site is selected from the group consisting of:

pre-frontal cortex;

orbitofrontal cortex;

anterior limb of the internal capsule;

nucleus accumbens;

inferior, middle, or superior frontal gyms;

medial frontal gyms;

ventral striatum;

ventral pallidum;

anterior nucleus of the thalamus;

dorsomedial nucleus of the thalamus;

intralaminar thalamic nuclei;

cingulate cortex;

amygdala;

hippocampus;

parahippocampal gyms;

pre-cuneus gyms;

anterior medial pallidum;

mamillary bodies;

lateral hypothalamus;

locus ceruleus;

dorsal raphe nucleus;

ventral tegmentum;

substantia nigra pars compacta or reticulata;

dorsal surface of the cerebellar hemisphere; and

anterior lateral surface of cerebellar hemispheres.

15. The method of claim 14, wherein the target site is selected from the group consisting of:

pre-frontal cortex;

orbitofrontal cortex;

anterior limb of the internal capsule;

nucleus accumbens;

inferior, middle, or superior frontal gyms;

medial frontal gyms;

ventral striatum;

ventral pallidum;

anterior nucleus of the thalamus;

dorsomedial nucleus of the thalamus;

cingulate cortex;

amygdala;

hippocampus;

parahippocampal gyms;

pre-cuneus gyms;

anterior medial pallidum;

mamillary bodies;

lateral hypothalamus;

locus cemleus;

dorsal raphe nucleus;

ventral tegmentum;

substantia nigra pars compacta or reticulata;

dorsal surface of the cerebellar hemisphere; and

anterior lateral surface of cerebellar hemispheres.