Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
First Claim
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1. A method of manufacturing a shape memory material, comprising the steps of:
- a) providing a generally cylindrical substrate having an outer surface capable of accommodating metal deposition thereupon;
b) vacuum depositing a metal onto the outer surface of the generally cylindrical substrate to form an unpatterned metal film on said outer surface of said generally cylindrical substrate, at least one of deposition chamber vacuum pressure, substrate temperature and bias voltage being controlled during the vacuum deposition to define a substantially homogeneous distribution of binding domains for endothelial cell attachment on the unpatterned metal film;
c) defining a pattern of a plurality of openings passing through the deposited unpatterned metal film on the outer surface of the generally cylindrical substrate; and
d) removing the generally cylindrical substrate from the patterned deposited metal film formed thereupon.
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Abstract
An implantable endoluminal device which is fabricated from materials which present a blood or body fluid and tissue contact surface which has controlled heterogeneities in material constitution. An endoluminal stent which is made of a material having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods.
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Citations
19 Claims
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1. A method of manufacturing a shape memory material, comprising the steps of:
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a) providing a generally cylindrical substrate having an outer surface capable of accommodating metal deposition thereupon; b) vacuum depositing a metal onto the outer surface of the generally cylindrical substrate to form an unpatterned metal film on said outer surface of said generally cylindrical substrate, at least one of deposition chamber vacuum pressure, substrate temperature and bias voltage being controlled during the vacuum deposition to define a substantially homogeneous distribution of binding domains for endothelial cell attachment on the unpatterned metal film; c) defining a pattern of a plurality of openings passing through the deposited unpatterned metal film on the outer surface of the generally cylindrical substrate; and d) removing the generally cylindrical substrate from the patterned deposited metal film formed thereupon. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of making an implantable medical device, comprising the steps of:
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a) providing a substrate having a shaped exterior surface capable of accommodating metal deposition thereupon; b) pre-cleaning the substrate in a vacuum deposition chamber by glow discharge; c) vacuum depositing a biocompatible material onto the shaped exterior surface of the substrate while controlling formation of heterogeneities in surfaces of the biocompatible material by controlling at least one of deposition chamber vacuum pressure, substrate temperature and substrate bias voltage, to define a substantially homogeneous distribution of binding domains for endothelial cell attachment to the surface of the deposited biocompatible material, the substantially homogeneous distribution of binding domains comprising a substantially repeating pattern along a blood contact surface of the surface of the deposited biocompatible material, the repeating pattern having a border-to-border spacing between adjacent binding domains of between about 1 to 2 microns; d) patterning the implantable medical device in the deposited biocompatible material; and e) removing the substrate from the patterned implantable medical device. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification