Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals
First Claim
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1. A stimuli-responsive acrylate hydrogel network comprising a calmodulin biopolymer monomer or multimer,wherein the hydrogel swells upon binding of a phenothiazine compound by the calmodulin biopolymer monomer or multimer.
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Abstract
A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting the mixture and polymerizing. The array can be used for high-throughput screening of analytes as well as for use as an actuator and biosensor using the swelling property of the hydrogel.
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6 Claims
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1. A stimuli-responsive acrylate hydrogel network comprising a calmodulin biopolymer monomer or multimer,
wherein the hydrogel swells upon binding of a phenothiazine compound by the calmodulin biopolymer monomer or multimer.
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Current AssigneeUniversity Of Kentucky Research Foundation (University of Kentucky)
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Original AssigneeUniversity Of Kentucky Research Foundation (University of Kentucky)
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InventorsBrowning, Tyler William, Ehrick, Jason Douglas, Deo, Sapna Kamlakar, Daunert, Sylvia, Bachas, Leonidas G.
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Primary Examiner(s)Noakes; Suzanne M.
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Assistant Examiner(s)Lee; Jae W
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Application NumberUS10/996,068Publication NumberTime in Patent Office1,833 DaysField of SearchNoneUS Class Current516/98CPC Class CodesG01N 33/54373 involving physiochemical en...G01N 33/84 involving inorganic compoun...
