MRI apparatus, flow quantification apparatus, and flow quantification method for ASL imaging

• US 7,627,360 B2
• Filed: 05/12/2003
• Issued: 12/01/2009
• Est. Priority Date: 05/13/2002
• Status: Expired due to Fees

• Current Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Original Assignee: Kabushiki Kaisha Toshiba (Toshiba Corporation)
• Inventors: Kimura, Tokunori
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): KISH, JAMES M
• Application Number:
  US10/435,682
• Publication Number:
  US 20040030240A1
• Time in Patent Office: 2,395 Days
• Field of Search: 600/410, 600/419, 324/306, 324/307, 324/309
• US Class Current: 600/419
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

An MRI apparatus is provided to quantify perfusion (microcirculatory blood flow in the tissue) in a region to be imaged in a subject based an ASL (arterial spin labeling) technique. The apparatus comprises imaging, storing, and flow quantifying units. The imaging unit performs a scan according to the ASL technique on the region so that image data is acquired from the region. The storing unit stores relationship information between a concentration of tracer (water) and a flow of the perfusion. The relationship is obtained on a two-compartment model that uses two compartments placed inside and outside of a flow of blood that diffuses into the tissue of the region and that considers temporal changes in the diffusion of the microcirculatory blood flow into the tissue. The flow quantifying unit quantifies the flow of the perfusion by applying an amount derived from the image data to the relationship information.

Claims

1. An MRI (Magnetic Resonance Imaging) apparatus comprising:

imaging means for acquiring image data by performing an ASL (Arterial Spin Labeling) scan on a patient region to be imaged;

storing means for storing information indicative of a relationship between a concentration of water tracer and a perfusion flow indicative of blood flow in tissue, the relationship being obtained based on a model that uses two compartments placed respectively inside and outside a flow of blood that diffuses into tissue of the region to be imaged and that takes into account temporal changes in diffusion of blood flow into the tissue; and

quantifying means for quantifying perfusion in the region to be imaged by using the image data and the relationship information between the tracer concentration and the perfusion flow;

wherein the quantifying means comprises;

means configured to obtain a plurality of tracer amounts existing within a unit voxel which respectively correspond to each of a plurality of known flows by applying to the model representative parameters of tissue in the region to be imaged;

means configured to approximate a relationship between the plurality of known flows and the plurality of tracer amounts using a polynomial expression which directly converts the tracer amounts into known flows using only coefficients of the polynomial expression as parameters; and

wherein the storing means comprises means configured to store, as correspondence information, a correspondence relationship based on the polynomial expression in the form of either a table or a conversion expression.

2. An MRI (Magnetic Resonance Imaging) apparatus comprising:

an imaging unit configured to acquire image data by performing an ASL (Arterial Spin Labeling) scan on a region to be imaged;

a storing unit configured to store information indicative of a relationship between a concentration of water tracer and a perfusion flow indicative of blood flow in tissue, the relationship being obtained based on a model that uses two compartments placed respectively inside and outside a flow of blood that diffuses into tissue of the region to be imaged and that takes into account temporal changes in diffusion of blood flow into the tissue; and

a flow quantifying unit configured to quantify perfusion flow in the region to be imaged by using the image data and the relationship information between the tracer concentration and the perfusion flow;

wherein the flow quantifying unit comprises;

means configured to obtain a plurality of tracer amounts existing within a unit voxel which respectively correspond to each of a plurality of known flows by applying to the model representative parameters of tissue in the region to be imaged;

means configured to approximate a relationship between the plurality of known flows and the plurality of tracer amounts using a polynomial expression which directly converts the tracer amounts into known flows using only coefficients of the polynomial expression as parameters; and

wherein the storing unit comprises means configured to store, as correspondence information, a correspondence relationship based on the polynomial expression in the form of either a table or a conversion expression.

3. The MRI apparatus according to claim 2, wherein the flow quantifying unit comprises:

means configured to obtain an amount of the tracer within a unit voxel from signal intensities of image data based on the ASL scan; and

means configured to convert the amount of the tracer into the perfusion flow using either the table or the conversion expression.

4. The MRI apparatus according to claim 3, wherein the obtaining means is configured to obtain an ASLR (ASL signal to control signal ratio image) from the image data based on the ASL scan and to calculate the amount of the tracer using the ASLR image.

5. The MRI apparatus according to claim 2, wherein the storing unit comprises means configured to use reference data to correct the correspondence relationship between the tracer concentration and the perfusion flow.

6. A flow quantification apparatus in which a model indicating a diffusion state of a flow of blood that diffuses into tissue of a subject region to be imaged is used for quantifying a perfusion flow in the region to be imaged, the apparatus comprising:

a magnetic resonance imaging (MRI) means for performing magnetic resonance imaging of a subject region;

a storing unit configured to store correspondence information between a concentration of water tracer and a perfusion flow indicative of blood flow in tissue of the region to be imaged, the relationship being obtained based on a model that uses two compartments placed respectively inside and outside the flow of blood that diffuses into tissue of the region to be imaged and that takes into account temporal changes in diffusion of blood flow into the tissue; and

a flow quantifying unit configured to quantify the perfusion flow in the region to be imaged by using image data obtained by imaging means and the correspondence information between the tracer concentration and the perfusion flow;

wherein the flow quantifying unit comprises;

means configured to obtain a plurality of amounts of the tracer existing within a unit voxel which each respectively correspond to one of a plurality of known flows by applying to a model representative parameters of tissue in the region to be imaged;

means configured to approximate a relationship between the plurality of known flows and the plurality of amounts of the tracer using a polynomial expression which directly converts the tracer amounts into known flows using only coefficients of the polynomial expression as parameters; and

wherein the storm unit comprises means configured to store, as the correspondence information, a correspondence relationship based on the polynomial expression in the form of either a table or a conversion expression, the correspondence relationship being applied to quantifying the perfusion flow in the region to be imaged.

7. The flow quantification apparatus according to claim 6, wherein the imaging means is configured to obtain the image data by performing a scan based on a VS-ASL (Velocity Selective Arterial Spin Labeling) technique.

8. A flow quantification method in which a model indicating a diffusion state of a flow of blood that diffuses into tissue of a region to be imaged of a subject to be examined is used for quantifying a perfusion flow in the region to be imaged, said method comprising:

use of a magnetic resonance imaging (MRI) means to acquire MRI data from patient tissue of a region to be imaged, including;

storing correspondence information between a concentration of water tracer and perfusion flow indicative of blood flow in tissue of the region to be imaged, the relationship being obtained based on a model that uses two compartments placed respectively inside and outside the flow of blood that diffuses into tissue of the region to be imaged and that takes into account temporal changes in diffusion of blood flow into the tissue; and

quantifying perfusion flow in the region to be imaged by using image data of the subject and the correspondence information between the tracer concentration and the perfusion flow;

wherein the quantifying step comprises;

obtaining a plurality of amounts of the tracer existing within a unit voxel which each respectively correspond to one of plural known flows by applying, to the model, representative parameters of the tissue in the region to be imaged;

approximating a relationship between the plurality of known flows and the plurality of amounts of the tracer using a polynomial expression which directly converts the tracer amounts into known flows using only coefficients of the polynomial expression as parameters; and

wherein the storing step comprises storing as the correspondence information, a correspondence relationship based on the polynomial expression in the form of either a table or a conversion expression.