Method and apparatus for cell and electrical therapy of living tissue
First Claim
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1. A method for enhancing cell therapy of cardiac tissue, comprising:
- programming a pacing mode adapted to enhance the cell therapy and including a first type pacing therapy including specialized cell therapy pacing cycles and a second type pacing therapy;
programming a duty cycle being a ratio of pacing of the first type pacing therapy to pacing of the second type pacing therapy; and
applying electrical therapy using an implantable pulse generator to cardiac tissue administered with exogenous cell therapy comprising donor cells,wherein the electrical therapy includes the pacing mode and enhances one or more of engraftment, survival, proliferation, differentiation and function of the donor cells.
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Abstract
A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
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Citations
23 Claims
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1. A method for enhancing cell therapy of cardiac tissue, comprising:
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programming a pacing mode adapted to enhance the cell therapy and including a first type pacing therapy including specialized cell therapy pacing cycles and a second type pacing therapy; programming a duty cycle being a ratio of pacing of the first type pacing therapy to pacing of the second type pacing therapy; and applying electrical therapy using an implantable pulse generator to cardiac tissue administered with exogenous cell therapy comprising donor cells, wherein the electrical therapy includes the pacing mode and enhances one or more of engraftment, survival, proliferation, differentiation and function of the donor cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for electrical therapy of cardiac tissue of a heart, at least a portion of the cardiac tissue administered with exogenous cells in a cell therapy, comprising:
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one or more catheter leads with electrodes; and a pulse generator comprising an interface configured to connect to the one or more catheter leads, a controller programmable for a plurality of pulse delivery modes, and a sense amplifier for sensing electrical signals from the one or more catheter leads, the pulse generator programmed to include a selectable pacing mode adapted to enhance the cell therapy, the selectable pacing mode adapted to provide a first type pacing therapy and a second type pacing therapy delivered at a duty cycle being a ratio of pacing of the first type pacing therapy to pacing of the second type pacing therapy, the first type pacing therapy adapted to enhance the cell therapy and including the specialized cell therapy pacing cycles. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification