System and method for evaluating and optimizing the contribution of particular heart chambers to the overall efficacy of cardiac pacing therapy

• US 7,627,374 B1
• Filed: 06/02/2006
• Issued: 12/01/2009
• Est. Priority Date: 06/02/2006
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Farazi, Taraneh Ghaffari, Park, Euljoon
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/421,936
• Time in Patent Office: 1,278 Days
• Field of Search: 607/7, 607/9, 607/11, 607/17, 607/28
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD

Abstract

Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.

Claims

1. A method for use in delivering cardiac pacing therapy to the heart of a patient in which an implantable cardiac stimulation device is implanted, the method comprising the steps of:

delivering cardiac pacing therapy to the heart of a patient using a pacing mode, the pacing mode specifying which chambers of the heart are paced;

temporarily altering the pacing mode with which pacing therapy is delivered;

detecting transient changes in the efficacy of pacing therapy following the alteration in pacing mode;

determining the contribution of particular heart chambers to the overall efficacy of pacing therapy based on the alteration in the pacing mode and on any transient changes in the efficacy of the pacing therapy; and

recording diagnostic information indicative of the contribution of particular heart chambers to the overall efficacy of pacing therapy.

2. The method of claim 1 further comprising adjusting selected pacing parameters so as to optimize the contribution of a particular heart chamber to the overall efficacy of pacing therapy.

3. The method of claim 2 wherein adjusting selected pacing parameters comprises:

incrementally adjusting V-V delay values throughout a range of V-V values;

temporarily switching the pacing mode from biventricular pacing to RV-only pacing at each particular V-V value; and

determining the contribution of the LV to pacing efficacy at each particular V-V value.

4. The method of claim 3 wherein adjusting selected pacing parameters further comprising selecting the V-V value that yields the greatest contribution of the LV to pacing efficacy for use in further biventricular pacing.

5. The method of claim 2 wherein adjusting selected pacing parameters so as to optimize the contribution of the particular heart chamber to the overall efficacy of pacing therapy comprises:

incrementally adjusting A-V delay values throughout a range of A-V values;

temporarily switching from dual-chamber pacing to ventricular-only pacing at each particular A-V value; and

evaluating the contribution of the atria to pacing efficacy at each particular A-V value.

6. The method of claim 5 wherein adjusting selected pacing parameters further comprising selecting the A-V value that yields the greatest contribution of the atria to pacing efficacy for use in further dual-chamber pacing.

7. The method of claim 1 wherein temporarily altering the pacing mode is performed by switching between a biventricular pacing mode and a monoventricular pacing mode.

8. The method of claim 1 wherein temporarily altering the pacing mode is performed by switching between a dual-chambered pacing mode, wherein pacing is performed in both the atria and ventricles, and a non-dual-chambered pacing mode, wherein pacing is exclusively performed in either the atria or the ventricles.

9. The method of claim 1 wherein temporarily altering the pacing mode is performed by switching among any of:

AAI;

VVI;

DDD;

DDI;

VDD; and

VOO pacing modes.

10. The method of claim 1 wherein temporarily altering the pacing mode is performed for a duration in the range of two to sixty seconds.

11. The method of claim 1 wherein detecting transient changes in the efficacy of pacing therapy following the alteration in pacing mode includes the steps of:

sensing signals representative of the effectiveness of pacing therapy; and

detecting any transient changes in the signals.

12. The method of claim 11 wherein sensing signals representative of the effectiveness of pacing therapy includes sensing signals representative of one or more of:

morphological features of an intracardiac electrogram (IEGM);

blood oxygen saturation;

blood pressure;

contractility;

stroke volume;

cardiac output; and

a heart output pulse waveform.

13. The method of claim 11 wherein detecting transient changes in the signals includes detecting transient changes in the peak amplitude of the signals.

14. The method of claim 1 wherein determining the contribution of particular heart chambers to the overall efficacy of pacing therapy includes:

detecting a lack of contribution by a particular heart chamber, if there is no significant change in the efficacy of pacing therapy following the alteration in the pacing mode; and

detecting a significant contribution by a particular heart chamber, if there is significant change in the efficacy of pacing therapy following the alteration in pacing mode.

15. A method for use in delivering cardiac pacing therapy to the heart of a patient in which an implantable cardiac stimulation device is implanted, the method comprising the steps of:

delivering cardiac pacing therapy to the heart of a patient using a pacing mode, the pacing mode specifying which chambers of the heart are paced;

temporarily altering the pacing mode with which pacing therapy is delivered;

detecting transient changes in the efficacy of pacing therapy following the alteration in pacing mode;

determining the contribution of particular heart chambers to the overall efficacy of pacing therapy based on the alteration in the pacing mode and on any transient changes in the efficacy of the pacing therapy; and

tracking changes over time in the contribution of particular heart chambers to the overall efficacy of pacing therapy.

16. The method of claim 15 further including the step of generating warning signals if the contribution of particular heart chambers to the overall efficacy of pacing therapy falls below a predetermined minimum acceptable amount.

17. The method of claim 15 wherein the heart is paced subject to one or more pacing parameters that affect the efficacy of pacing therapy and wherein the method further includes the step of adjusting the pacing parameters based on the contribution of particular heart chambers to the overall efficacy of pacing therapy.

18. The method of claim 17 wherein the pacing parameters include one or more of:

an atrioventricular (A-V) delay;

an inter-ventricular (V-V) delay; and

an inter-atrial (A-A) delay.

19. The method of claim 17 wherein adjusting the pacing parameters is performed to increase the contribution of a particular heart chamber.

20. The method of claim 17 wherein adjusting the pacing parameters is performed to maximize the contribution of the particular heart chamber.