Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors
First Claim
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1. A method for detecting and correcting a misalignment of a microplate in an optical reader system, said method comprising the steps of:
- placing said microplate onto a holder;
scanning a fiducial marking on said microplate to determine a first position of said microplate;
removing said microplate from said holder;
re-inserting said microplate back onto said holder;
scanning said fiducial marking on said microplate to determine a second position of said microplate;
comparing the first position and the second position of said microplate; and
if there is a difference between the two positions, then addressing the lateral and/or angular misalignment of said microplate such that the re-inserted microplate is positioned to be located at or substantially near to the first position, wherein the fiducial marking includes features that are at one angle to a scanning direction of an optical beam and features that are at a second angle to the scanning direction of the optical beam which enables one to determine misalignments if any in two directions.
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Abstract
An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
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Citations
12 Claims
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1. A method for detecting and correcting a misalignment of a microplate in an optical reader system, said method comprising the steps of:
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placing said microplate onto a holder; scanning a fiducial marking on said microplate to determine a first position of said microplate; removing said microplate from said holder; re-inserting said microplate back onto said holder; scanning said fiducial marking on said microplate to determine a second position of said microplate; comparing the first position and the second position of said microplate; and if there is a difference between the two positions, then addressing the lateral and/or angular misalignment of said microplate such that the re-inserted microplate is positioned to be located at or substantially near to the first position, wherein the fiducial marking includes features that are at one angle to a scanning direction of an optical beam and features that are at a second angle to the scanning direction of the optical beam which enables one to determine misalignments if any in two directions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification