NF-κB activating gene
First Claim
Patent Images
1. An isolated polynucleotide which comprises a nucleotide sequence encoding a protein that activates NF-κ
- B and which comprises an amino acid sequence represented by SEQ ID NO;
162 or an amino acid sequence 96% identical thereto over the entire length thereof.
0 Assignments
0 Petitions
Accused Products
Abstract
Provided are proteins having NF-κB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-κB. Using plasmid pNF κB-Luc, cDNA encoding a protein capable of activating NF-κB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-κB activation.
-
Citations
9 Claims
-
1. An isolated polynucleotide which comprises a nucleotide sequence encoding a protein that activates NF-κ
- B and which comprises an amino acid sequence represented by SEQ ID NO;
162 or an amino acid sequence 96% identical thereto over the entire length thereof. - View Dependent Claims (5, 6, 7, 8, 9)
- B and which comprises an amino acid sequence represented by SEQ ID NO;
-
2. An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:
-
(a) a polynucleotide sequence represented by SEQ ID No;
161; and(b) a polynucleotide sequence encoding a protein that activates NF-κ
B and that hybridizes under stringent conditions with a polynucleotide having a polynucleotide sequence complementary to the polynucleotide sequence of (a).
-
-
3. An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:
-
(a) a nucleotide sequence represented by a coding region in SEQ ID NO;
161; and(b) a nucleotide sequence encoding a protein that activates NF-κ
B and that hybridizes under stringent conditions with a polynucleotide having a polynucleotide sequence complementary to the polynucleotide sequence of (a).
-
-
4. An isolated polynucleotide comprising a nucleotide sequence which encodes a protein that activates NF-κ
- B and has at least 95% identity to a polynucleotide having the sequence of the coding protein of SEQ ID NO;
161 over the entire length thereof.
- B and has at least 95% identity to a polynucleotide having the sequence of the coding protein of SEQ ID NO;
Specification