Particle beam irradiation method using depth and lateral direction irradiation field spread and particle beam irradiation apparatus used for the same

• US 7,629,598 B2
• Filed: 02/04/2005
• Issued: 12/08/2009
• Est. Priority Date: 02/04/2005
• Status: Active Grant

• Current Assignee: Mitsubishi Denki Kabushiki Kaisha (Mitsubishi Electric Corporation)
• Original Assignee: Mitsubishi Denki Kabushiki Kaisha (Mitsubishi Electric Corporation)
• Inventors: Harada, Hisashi
• Primary Examiner(s): Berman; Jack I
• Assistant Examiner(s): IPPOLITO, NICOLE MARIE
• Application Number:
  US11/632,910
• Publication Number:
  US 20070295910A1
• Time in Patent Office: 1,768 Days
• Field of Search: 250/492.1, 250/492.3, 250/503.1, 250/493.1, 250/505.1, 600/411, 600/407, 600/413, 600/410, 600/414, 600/415, 600/421, 600/436, 315/503, 315/501, 315/502, 315/505, 378/64, 378/65, 378/69, 378/145, 378/156, 378/137, 378/158, 378/159
• US Class Current: 250/492.3
• CPC Class Codes: A61B 2090/3945 Active visible markers, e.g. light emitting diodes
• CPC Class Codes: A61N 2005/105 using a laser alignment system
• CPC Class Codes: A61N 2005/1059 using cameras imaging the patient
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

In a particle beam irradiation method and a particle beam irradiation apparatus in which depth direction irradiation field spread and lateral direction irradiation field spread are performed, an irradiation dose in each of the irradiation layers of an irradiation target is made substantially constant, the control is simplified, and the irradiation error by the displacement of the irradiation target is reduced. The depth direction irradiation field spread is an active irradiation field spread to superimpose plural irradiation layers having different ranges in the irradiation direction of the particle beam. A bolus having a shape along a deepest part of the irradiation target in the depth direction is disposed to cross the particle beam. At least one irradiation layer selected from the plural irradiation layers is re-irradiated one or more times with the particle beam.

Claims

1. A particle beam irradiation method which uses both a depth direction irradiation field spread for spreading an irradiation field of a particle beam in a depth direction along an irradiation direction of the particle beam, and a lateral direction irradiation field spread for spreading the irradiation field of the particle beam in a lateral direction perpendicular to the irradiation direction of the particle beam, and irradiates the particle beam at an irradiation target, the method comprising:

superimposing plural irradiation layers having different ranges in the irradiation direction of the particle beam, the depth direction irradiation field spread being an active irradiation field spread;

disposing a bolus having a shape along a deepest part of the irradiation target in the depth direction is disposed to cross the particle beam;

re-irradiating at least one selected irradiation layer selected from the plural irradiation layers one or more times with the particle beam for irradiating a planned irradiation dose of the particle beam for the one selected irradiation layer, the one selected irradiation layer is a deepest irradiation layer among the plural irradiation layers;

detecting a displacement of the irradiation target when the irradiation target is displaced; and

adjusting an irradiation dose of the particle beam according to the displacement of the irradiation target so that the planned irradiation dose of the particle beam for the one selected irradiation layer is obtained, even if the one selected irradiation layer is displaced.

2. The particle beam irradiation method according to claim 1, wherein the lateral direction irradiation field spread is an active irradiation field spread in which irradiation spots of the particle beam are superimposed in the lateral direction.

3. The particle beam irradiation method according to claim 1, wherein the lateral direction irradiation field spread is a passive irradiation field spread.

4. The particle beam irradiation method according to claim 1, wherein the selected irradiation layer is an irradiation layer having a highest irradiation dose in the plural irradiation layers, and the selected irradiation layer is re-irradiated one or more times with the particle beam.

5. The particle beam irradiation method according to claim 1, wherein plural selected irradiation layers are selected from the plural irradiation layers, and each of the plural selected irradiation layers is re-irradiated one or more times with the particle beam, for irradiating each of the planned irradiation dose of the particle beam for each of the plural selected irradiation layers.

6. The particle beam irradiation method according to claim 5, wherein the number of times of reirradiation for each of the plural selected irradiation layers is the number of times corresponding to the planned irradiation dose for each of the selected irradiation layers.

7. The particle beam irradiation method according to claim 1, wherein when the displacement of the irradiation target is detected, turning on/off the irradiation of the particle beam is performed according to the displacement of the irradiation target.

8. The particle beam irradiation method according to claim 1, wherein in a case where the irradiation target is displaced mainly along a specified direction, the particle beam is irradiated to the irradiation target from a direction oblique to the specified direction.

9. A particle beam irradiation apparatus comprising:

a particle beam generation part for generating a particle beam;

a particle beam transport part for transporting the particle beam generated by the particle beam generation part;

a particle beam irradiation part for irradiating the particle beam transported by the particle beam transport part at an irradiation target;

depth direction irradiation field spread means for spreading an irradiation field of the particle beam in a depth direction along an irradiation direction of the particle beam;

lateral direction irradiation field spread means for spreading the irradiation field of the particle beam in a lateral direction perpendicular to the irradiation direction of the particle beam, wherein

the depth direction irradiation field spread means is an active depth direction irradiation field spread means for superimposing plural irradiation layers having different ranges in the irradiation direction of the particle beam, and

wherein the particle beam irradiation apparatus further comprises;

a bolus having a shape along a deepest part of the irradiation target in the depth direction is disposed to cross the particle beam;

means for re-irradiating the particle beam to at least one selected irradiation layer selected from the plural irradiation layers one or more times with the particle beam for irradiating a planned irradiation dose of the particle beam for the one selected irradiation layer, the one selected irradiation layer is a deepest irradiation layer among the plural irradiation layers;

displacement detection means for detecting a displacement of the irradiation target; and

adjustment means for adjusting an irradiation dose of the particle beam according to the displacement of the irradiation target so that the planned irradiation dose of the particle beam for the one selected irradiation layer is obtained, even if the one selected irradiation layer is displaced.

10. The particle beam irradiation apparatus according to claim 9, wherein the active depth direction irradiation field spread means is coupled to an accelerator for accelerating the particle beam, and for changing an acceleration energy of the particle beam.

11. The particle beam irradiation apparatus according to claim 9, wherein the active depth direction irradiation field spread means is a range shifter disposed to cross the particle beam, and the range shifter adjusts energy of the particle beam according to a given adjustment signal.

12. The particle beam irradiation apparatus according to claim 9, wherein the lateral direction irradiation field spread means is an active irradiation field spread means for superimposing irradiation spots of the particle beam in the lateral direction.

13. The particle beam irradiation apparatus according to claim 9, wherein the lateral direction irradiation field spread means is a passive irradiation field spread means.

14. The particle beam irradiation apparatus according to claim 9, wherein the particle beam irradiation apparatus further comprises a displacement detection means for detecting a displacement of the irradiation target, and a turning on/off means for turning on/off irradiation of the particle beam, wherein the particle beam is turned on/off according to the displacement of the irradiation target.

15. The particle beam irradiation apparatus according to claim 9, wherein the particle beam irradiation part includes an irradiation nozzle to irradiate the particle beam, the irradiation nozzle is mounted on a rotation gantry, and in a case where the irradiation target is displaced mainly along a specified direction, the particle beam is irradiated to the irradiation target from a direction oblique to the specified direction.