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System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject

  • US 7,630,757 B2
  • Filed: 08/01/2002
  • Issued: 12/08/2009
  • Est. Priority Date: 01/06/1997
  • Status: Active Grant
First Claim
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1. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, and of quantifying said changes of activity states, comprising the steps of:

  • (a) receiving into a signal processor input signals indicative of the subject'"'"'s brain activity;

    (b) determining at least one ictal component in said input signals by applying to said input signals a first filter configured for extracting and enhancing the at least one ictal component from said input signals;

    (c) measuring the ictal activity in a foreground epoch of said input signals by applying at least one order-statistic filter to said ictal components corresponding to said epoch to produce a foreground measure of said ictal activity;

    (d) determining whether said foreground measure reaches a threshold level, such being indicative of the occurrence of a change in activity state in the brain of a subject;

    (e) quantifying at least one measure of said change in activity state selected from the group consisting of onset location, pattern of spread, intensity, time-frequency evolution, and frequency of occurrence;

    (f) performing steps (a)-(d) while said change in activity state is occurring and before the onset of electroencephalographic waves of said change in activity state; and

    (g) analyzing subsequent seizure signal changes to verify that said change in activity state has occurred.

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