Method for detecting filter clogging by using pressure information, apparatus for monitoring filter clogging and bed-side system
First Claim
1. A method for detecting filter clogging comprising:
- flowing blood through a hollow-fiber membrane from a blood inflow portion to a blood outflow portion, a waste liquid from the blood passing through the hollow filter membrane into a filtrate region;
flowing a filtrate into the filtrate region through a filtrate inflow portion and out of a filtrate outflow portion;
measuring pressure over time in at least two of the blood inflow portion, the blood outflow portion, the filtrate inflow portion, and the filtrate outflow portion and generating measured pressure signals indicative thereof;
analyzing the measured pressure signals including determining a transform of the measured pressure signals and a difference of a phase in the transformed measured pressure signals indicative of measured pressure in at least two of the blood inflow portion, the blood outflow portion, the filtrate inflow portion, and the filtrate outflow portion;
in response to determining a difference in the phase that is indicative of clogging of the hollow-fiber membrane, at least one of display filter clogging status and adjusting an amount of anti-coagulant in the blood entering the blood inflow portion.
1 Assignment
0 Petitions
Accused Products
Abstract
A method is provided for detecting filter clogging which are able to keep track of the filter clogging with precision and in detail. At least one pressure selected from the group consisting of a pressure Pa in a blood inflow portion (32a), a pressure Pv in a blood outflow portion (32b), a pressure Pf1 in a filtrate inflow portion (32c), and a pressure Pf2 in a filtrate outflow portion (32d) is measured continuously, then a variation (pressure waveform) of the pressure is analyzed, a clogging of a filter (32) is detected using the analyzed result. Thereby a clogging of a filter is detected early. As a result, it is possible to prevent from developing of the filter clogging by controlling a dosage amount of anti-coagulant properly and changing a flow rate of blood. The variation of the pressure wave may be analyzed by subjecting the variable to Fast Fourier Transform.
17 Citations
13 Claims
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1. A method for detecting filter clogging comprising:
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flowing blood through a hollow-fiber membrane from a blood inflow portion to a blood outflow portion, a waste liquid from the blood passing through the hollow filter membrane into a filtrate region; flowing a filtrate into the filtrate region through a filtrate inflow portion and out of a filtrate outflow portion; measuring pressure over time in at least two of the blood inflow portion, the blood outflow portion, the filtrate inflow portion, and the filtrate outflow portion and generating measured pressure signals indicative thereof; analyzing the measured pressure signals including determining a transform of the measured pressure signals and a difference of a phase in the transformed measured pressure signals indicative of measured pressure in at least two of the blood inflow portion, the blood outflow portion, the filtrate inflow portion, and the filtrate outflow portion; in response to determining a difference in the phase that is indicative of clogging of the hollow-fiber membrane, at least one of display filter clogging status and adjusting an amount of anti-coagulant in the blood entering the blood inflow portion. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for monitoring a filter clogging comprising:
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pressure sensors for detecting pressures in at least two of a blood inflow portion, a blood outflow portion, a filtrate inflow portion, and a filtrate outflow portion of a blood dialysis filter, and generating pressure signals indicative thereof; a calculation section which analyzes the detected pressures by transforming the measured pressures, determining phase of the pressure signals, determining changes in the phase of the pressure signals, and a clogging status of the filter based on changes in the phase; a display for displaying the filter clogging status determined by the calculation section; and a medical dosage section, the calculation section controls the medical dossage section to adjust an amount of anticoagulant introduced in blood pumped to the blood inflow portion in accordance with the clogging status. - View Dependent Claims (7, 8, 9)
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10. A bedside blood filter apparatus comprising:
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a blood filter including a blood inflow portion, a blood outflow portion, and a hollow-fiber membrane disposed between the blood inflow portion and the blood outflow portion, waste products from the blood passing through the hollow fiber membrane; a filtrate inflow portion for receiving a liquid filtrate and a filtrate outflow portion through which the filtrate and the waste products are discharged; a plurality of pressure sensors disposed in at least one of the blood inflow portion, the blood outflow portion, the filtrate inflow portion, and the filtrate outflow portion; a pump for pumping blood to the blood inflow portion; a calculation section which calculates a clogging status of the hollow-fiber filter, the calculation section including a processor programmed to determine changes in phase of the measured pressure and determining the clogging status in accordance with the determined phase changes; a medical dosage section, the calculation section controls the medication dosage section to adjust an amount of anticoagulant introduced into blood pumped to the blood inflow portion in accordance with the determined clogging status. - View Dependent Claims (11, 12, 13)
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Specification