Method for measurement of analyte concentrations and semiconductor laser-pumped, small-cavity fiber lasers for such measurements and other applications
First Claim
1. A method of determining the concentration of an analyte in a specimen comprising the steps of:
- providing a hybrid laser that comprises a first and second laser for producing at a single output a plurality of emission wavelengths that substantially match distinguishing wavelength spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte;
modulating the first laser with a plurality of tone frequencies where at least one of said tone frequencies is above a maximum frequency response of the second laser so that at least one emission wavelength from the second laser is not modulated by a tone frequency;
applying the modulated output emission wavelengths to the specimen under examination;
detecting radiation reflected, scattered or passed through the specimen;
producing a set of values representative of wavelength spectral characteristic features of the analyte within the characteristic optical spectrum portion from the applied modulated output emission wavelengths and the detected reflected radiation; and
determining the differences in the produced set of values with predetermined reference values representative of desired wavelength spectral characteristic features of the analyte to produce a final value representative of a measurement of concentration of the analyte in the specimen.
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Abstract
A hybrid laser comprising a semiconductor pump laser and small-cavity rare earth fiber laser where laser cavities of both lasers are butt coupled or otherwise optically coupled to form a plurality of laser cavities that produce a plurality of emission wavelengths, one which may be the pump laser emission wavelength at the output of the fiber laser thereby forming a multi-wavelength combined output. The wavelengths in such an output may substantially match distinguishing spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte under examination providing a method of determining the concentration of an analyte in a specimen undergoing examination.
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Citations
15 Claims
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1. A method of determining the concentration of an analyte in a specimen comprising the steps of:
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providing a hybrid laser that comprises a first and second laser for producing at a single output a plurality of emission wavelengths that substantially match distinguishing wavelength spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte; modulating the first laser with a plurality of tone frequencies where at least one of said tone frequencies is above a maximum frequency response of the second laser so that at least one emission wavelength from the second laser is not modulated by a tone frequency; applying the modulated output emission wavelengths to the specimen under examination; detecting radiation reflected, scattered or passed through the specimen; producing a set of values representative of wavelength spectral characteristic features of the analyte within the characteristic optical spectrum portion from the applied modulated output emission wavelengths and the detected reflected radiation; and determining the differences in the produced set of values with predetermined reference values representative of desired wavelength spectral characteristic features of the analyte to produce a final value representative of a measurement of concentration of the analyte in the specimen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. An optical spectroscopy apparatus for determining the concentration of analyte in a specimen that utilizes a radiation source comprising at least one combination of a semiconductor pump laser and small-cavity fiber laser where laser cavities of both lasers are butt coupled to provide a plurality of laser resonant cavities where the cavities are all, at least in part, formed by fiber Bragg gratings formed in the core of the laser fiber that produce a plurality of emission wavelengths at a same output of the butt coupled laser that are designed to substantially match distinguishing spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte under determination.
- 12. A multi-cavity laser having a multi-wavelength output at one end, comprising a semiconductor pump laser optically coupled to a short cavity fiber laser having a rare earth doped core, the multi-cavity laser having a first resonator cavity formed by the laser cavities of the semiconductor laser and the fiber laser via a first mirror at one end of the semiconductor laser cavity and a mirror at the one end and at least one second resonator cavity formed in the fiber laser cavity with, respectively, a second and third mirror at each end of the fiber lasing cavity forming the second resonator cavity, the first, second and third mirrors formed as fiber Bragg gratings in the rare earth doped core.
Specification