Techniques for applying, calibrating, and controlling nerve fiber stimulation
First Claim
Patent Images
1. Apparatus comprising:
- an electrode device, configured to be coupled to a site of a subject;
an electrocardiogram (ECG) monitor, configured to detect a feature of an ECG of the subject; and
a control unit, configured to;
drive the electrode device to apply to the site intermittent electrical stimulation during “
on”
periods, which electrical stimulation includes a series of bursts that commence in respective cardiac cycles after a delay after the feature of the ECG detected by the ECG monitor, wherein each of the bursts includes at least one pulse, wherein the “
on periods”
alternate with “
off”
periods in which the stimulation is not applied, and wherein each of the “
on”
periods has an “
on”
duration equal to at least 1 second, and each of the “
off”
periods has an “
off”
duration equal to at least 50% of the “
on”
duration,responsively to the sensed heart rate, set at least one parameter of the stimulation,compare (a) a ratio of (i) a duration of each “
on”
period to (ii) the sum of the duration of each “
on”
period and a duration of each “
off”
period to (b) a quotient of a number of bursts of the stimulation applied divided by a number of heart beats during the “
on” and
“
off”
periods, anddetect a presence of a heart-rate-lowering effect of the stimulation responsively to finding that the quotient is less than the ratio.
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Abstract
Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.
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Citations
6 Claims
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1. Apparatus comprising:
-
an electrode device, configured to be coupled to a site of a subject; an electrocardiogram (ECG) monitor, configured to detect a feature of an ECG of the subject; and a control unit, configured to; drive the electrode device to apply to the site intermittent electrical stimulation during “
on”
periods, which electrical stimulation includes a series of bursts that commence in respective cardiac cycles after a delay after the feature of the ECG detected by the ECG monitor, wherein each of the bursts includes at least one pulse, wherein the “
on periods”
alternate with “
off”
periods in which the stimulation is not applied, and wherein each of the “
on”
periods has an “
on”
duration equal to at least 1 second, and each of the “
off”
periods has an “
off”
duration equal to at least 50% of the “
on”
duration,responsively to the sensed heart rate, set at least one parameter of the stimulation, compare (a) a ratio of (i) a duration of each “
on”
period to (ii) the sum of the duration of each “
on”
period and a duration of each “
off”
period to (b) a quotient of a number of bursts of the stimulation applied divided by a number of heart beats during the “
on” and
“
off”
periods, anddetect a presence of a heart-rate-lowering effect of the stimulation responsively to finding that the quotient is less than the ratio. - View Dependent Claims (2, 3)
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4. A method comprising:
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detecting a feature of an electrocardiogram (ECG) of a subject; applying to a site of the subject intermittent electrical stimulation during “
on”
periods, which electrical stimulation includes a series of bursts that commence in respective cardiac cycles after a delay after the detected feature of the ECG, wherein each of the bursts includes at least one pulse, wherein the “
on periods”
alternate with “
off”
periods in which the stimulation is not applied, and wherein each of the “
on”
periods has an “
on”
duration equal to at least 1 second, and each of the “
off”
periods has an “
off”
duration equal to at least 50% of the “
on”
duration;responsively to the sensed heart rate, setting at least one parameter of the stimulation; comparing (a) a ratio of (i) a duration of each “
on”
period to (ii) the sum of the duration of each “
on”
period and a duration of each “
off”
period to (b) a quotient of a number of bursts of the stimulation applied divided by a number of heart beats during the “
on” and
“
off”
periods; anddetecting a presence of a heart-rate-lowering effect of the stimulation responsively to finding that the quotient is less than the ratio. - View Dependent Claims (5, 6)
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Specification
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Current AssigneeMedtronic Incorporated (Medtronic Plc)
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Original AssigneeBioControl Medical (B.C.M) Ltd.
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InventorsBen-Ezra, Omry, Cohen, Ehud, Ben-David, Tamir, Ayal, Shai
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Primary Examiner(s)BOCKELMAN, MARK
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Application NumberUS11/062,324Publication NumberTime in Patent Office1,761 DaysField of Search607/14, 607/118US Class Current607/14CPC Class CodesA61B 5/024 Detecting, measuring or rec...A61B 5/4029 for evaluating the peripher...A61B 5/4041 Evaluating nerves conditionA61B 5/412 Detecting or monitoring sepsisA61B 5/7217 of noise originating from a...A61N 1/0551 Spinal or peripheral nerve ...A61N 1/0556 Cuff electrodesA61N 1/36114 Cardiac control, e.g. by va...A61N 1/3621 for treating or preventing ...A61N 1/3627 for treating a mechanical d...
