Pressure-propelled system for body lumen

• US 7,635,345 B2
• Filed: 05/03/2004
• Issued: 12/22/2009
• Est. Priority Date: 01/09/2004
• Status: Active Grant

• Current Assignee: G.I. View Ltd.
• Original Assignee: G I View Limited
• Inventors: Degtiar, Boris, Shor, Eran, Gross, Yossi, Cabiri, Oz
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US10/838,648
• Publication Number:
  US 20050154355A1
• Time in Patent Office: 2,059 Days
• Field of Search: 604523-539, 604/264, 604/96.01, 60410101- 5, 60410201- 3, 604/916, 604/917, 604/920, 604/921, 604/99.01, 606191-194
• US Class Current: 604/99.01
• CPC Class Codes: A61B 1/00156 using self propulsion
• CPC Class Codes: A61B 1/126 provided with means for cleaning in-use
• CPC Class Codes: A61M 25/0122 with fluid drive by external fluid in an open fluid circuit

Abstract

Apparatus is provide for use with a fluid pressure source, including an elongate carrier, adapted to be inserted through a proximal opening of a body lumen, and a distal piston head coupled to a distal portion of the carrier. The piston head is adapted to be in direct contact with a wall of the lumen when the carrier is inserted into the lumen, and to be advanced distally through the body lumen in response to pressure from the fluid pressure source. Additionally, the piston head is typically adapted to facilitate passage of fluid out of the lumen from a site within the lumen distal to the piston head.

Claims

1. Apparatus for use with a biologically-compatible-fluid pressure source, comprising:

an elongate carrier, adapted to be inserted through a proximal opening of a colon of a GI tract;

an inflatable distal piston head coupled to a distal portion of the carrier and adapted to;

be in direct contact with a wall of the colon when the carrier is inserted into the colon, by being inflated, so as to attain and maintain the direct contact with the wall of the colon,

be advanced distally through the colon in response to pressure from the fluid pressure source impinging on a proximal side of the piston head, while the piston is in the inflated state, and

facilitate passage of fluid out of the colon from a site within the colon distal to the piston head;

a pressure sensor, adapted to measure a first pressure associated with operation of the apparatus; and

a control unit, adapted to regulate a second pressure associated with operation of the apparatus responsive to the measurement of the pressure sensor.

2. The apparatus according to claim 1, wherein an outer surface of the piston head in contact with the wall of the colon comprises a low friction coating suitable for facilitating sliding of the piston head against the wall of the colon.

3. The apparatus according to claim 1, wherein the apparatus comprises a vent tube, and wherein the piston head is adapted to facilitate the passage of the fluid out of the colon through the vent tube.

4. The apparatus according to claim 3, wherein the vent tube is shaped to define an inner diameter thereof that is between 1 and 3 millimeters.

5. The apparatus according to claim 3, wherein the vent tube is adapted to passively permit the passage of the fluid out of the colon.

6. The apparatus according to claim 3, wherein the vent tube is adapted to be coupled to a suction source, whereby to actively facilitate the passage of the fluid out of the colon.

7. The apparatus according to claim 6, wherein the vent tube is adapted to be coupled to the suction source such that during operation of the apparatus, a pressure distal to the piston head is between −

5 millibar and +15 millibar.

8. The apparatus according to claim 1, wherein the apparatus comprises an auxiliary piston head, coupled to the carrier at a position proximal to the distal piston head, wherein the auxiliary piston head is adapted to be inflated so as to attain and maintain direct contact with the wall of the colon, and wherein:

(a) at least one time while the carrier is within the colon, the distal piston head is adapted to be in a state of being already deflated at least in part simultaneously with the auxiliary piston head being already inflated and being advanced distally through the colon in response to pressure from the fluid pressure source, and

(b) at least one other time while the carrier is within the colon, the auxiliary piston head is adapted to be in a state of being already deflated at least in part simultaneously with the distal piston head being already inflated and being advanced distally through the colon in response to pressure from the fluid pressure source.

9. The apparatus according to claim 1, wherein the piston head is adapted to be intermittently deflated at least in part, while in the colon, whereby to facilitate the passage of the fluid out of the colon from the site within the colon distal to the piston head.

10. The apparatus according to claim 1, wherein the piston head is adapted to be at an inflation pressure between 10 and 60 millibar during advancement through the colon.

11. The apparatus according to claim 10, wherein the piston head is adapted to advance through the colon in response to a pressure from the fluid pressure source that is between 30% and 100% of the inflation pressure.

12. The apparatus according to claim 11, wherein the piston head is adapted to advance through the colon in response to a pressure from the fluid pressure source that is between 50% and 100% of the inflation pressure.

13. The apparatus according to claim 10, wherein the piston head is adapted to be at an inflation pressure between 20 and 50 millibar during advancement through the colon.

14. The apparatus according to claim 13, wherein the piston head is adapted to be at an inflation pressure between 30 and 45 millibar during advancement through the colon.

15. The apparatus according to claim 14, wherein the piston head is adapted to advance through the colon in response to a pressure from the fluid pressure source that is between 30% and 100% of the inflation pressure.

16. The apparatus according to claim 15, wherein the piston head is adapted to advance through the colon in response to a pressure from the fluid pressure source that is between 50% and 100% of the inflation pressure.

17. The apparatus according to claim 16, wherein the piston head is adapted to advance through the colon in response to a pressure from the fluid pressure source that is between 50% and 80% of the inflation pressure.

18. A method, comprising:

placing into a body lumen of a subject an inflatable distal piston head that is coupled to an elongate carrier;

gutting the inflatable distal piston head in direct contact with a wall of the body lumen by inflating the piston head;

advancing the piston head distally through the body lumen by conveying fluid pressure from a site outside of the subject to an external proximal surface of the distal piston head; and

facilitating passage of fluid out of the lumen from a site within the lumen distal to the piston head.

19. The method according to claim 18, comprising applying a low friction coating to an outer surface of the piston head intended for contact with the wall of the lumen, the low friction coating being suitable for facilitating sliding of the piston head against the wall of the lumen.

20. The method according to claim 18, wherein the lumen includes a gastrointestinal (GI) tract, and wherein placing the piston head comprises placing the piston head in direct contact with a wall of the GI tract.

21. The method according to claim 20, wherein the GI tract includes a colon, and wherein placing the piston head includes placing the piston head in direct contact with a wall of the colon.

22. The method according to claim 21, wherein facilitating the passage of the fluid comprises facilitating the passage of the fluid out of the lumen through a vent tube extending from the site distal to the piston head to a site outside of the lumen.

23. The method according to claim 22, wherein facilitating the passage of the fluid comprises passively permitting the passage of the fluid through the vent tube and out of the lumen.

24. The method according to claim 22, wherein facilitating the passage of the fluid comprises actively removing the fluid from the lumen.

25. The method according to claim 24, wherein actively removing the fluid comprises applying to the site distal to the piston head a pressure between −

5 millibar and +15 millibar.

26. The method according to claim 21, wherein placing the piston head in direct contact with the wall comprises inflating the piston head to an extent sufficient to attain and maintain the direct contact with the wall of the colon.

27. The method according to claim 26, wherein the method comprises:

placing an auxiliary piston head proximal to the distal piston head;

inflating the auxiliary piston head to an extent sufficient to attain and maintain direct contact with the wall of the colon;

at least one time while the distal piston head is within the body lumen, deflating the distal piston head at least in part, such that at a post-distal-piston-head-deflation time when the distal piston head is in a state of being already deflated at least in part, the auxiliary piston head is inflated and advancing distally through the colon in response to the applied fluid pressure; and

at least one other time while the distal piston head is within the body lumen, deflating the auxiliary piston head at least in part, such that at a post-auxiliary-piston-head-deflation time when the auxiliary piston head is in a state of being already deflated at least in part, the distal piston head is inflated and advancing distally through the colon in response to the applied pressure.

28. The method according to claim 26, wherein facilitating the passage of the fluid out of the lumen comprises intermittently deflating the piston head at least in part.

29. The method according to claim 26, wherein inflating the piston head comprises inflating the piston head at an inflation pressure between 10 and 60 millibar.

30. The method according to claim 29, wherein applying the fluid pressure comprises setting the fluid pressure to between 30% and 100% of the inflation pressure.

31. The method according to claim 30, wherein applying the fluid pressure comprises setting the fluid pressure to between 50% and 100% of the inflation pressure.

32. The method according to claim 29, wherein inflating the piston head comprises inflating the piston head at an inflation pressure between 20 and 50 millibar.

33. The method according to claim 32, wherein inflating the piston head comprises inflating the piston head at an inflation pressure between 30 and 45 millibar.

34. The method according to claim 33, wherein applying the fluid pressure comprises setting the fluid pressure to between 30% and 100% of the inflation pressure.

35. The method according to claim 34, wherein applying the fluid pressure comprises setting the fluid pressure to between 50% and 100% of the inflation pressure.

36. The method according to claim 35, wherein applying the fluid pressure comprises setting the fluid pressure to between 50% and 80% of the inflation pressure.