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Tissue engineering scaffolds promoting matrix protein production

  • US 7,635,592 B2
  • Filed: 08/21/2001
  • Issued: 12/22/2009
  • Est. Priority Date: 08/21/2000
  • Status: Expired due to Fees
First Claim
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1. A method for making a tissue engineering scaffold for inducing formation of extracellular matrix by cells bound to the scaffold comprising covalently coupling matrix-enhancing molecules are selected from the group consisting of TGF-β

  • , angiotensin II, insulin-like growth factor and ascorbic acid to the scaffold in an effective density to elicit production of extracellular matrix without increasing cellular proliferation, wherein when the matrix-enhancing molecules are TGF-β

    , the TGF-β

    is covalently coupled to the matrix by a polymer tether having a molecular weight between 2000 and 6000 and is in a density between 1 and 100 ng TGF-β

    /ml or in a concentration of between about 4×

    10

    6
    and 4×

    10

    3
    nmol/ml.

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