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Process for the preparation of oligonucleotides

  • US 7,635,772 B2
  • Filed: 12/16/2003
  • Issued: 12/22/2009
  • Est. Priority Date: 12/18/2002
  • Status: Active Grant
First Claim
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1. A process for the synthesis of an oligonucleotide in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of a solvent and an activator, wherein, the solvent and swellable support are selected such that a swell ratio of from 5 to 20 is achieved, swell ratio being calculated according to the formula:

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