Fully implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders
First Claim
Patent Images
1. A fully implantable nerve stimulation system, comprising:
- at least one nerve cuff so configured as to receiving part of a nerve, the nerve cuff having electrodes therein positioned in the vicinity of nerve fibers;
a control unit including;
a power source;
a processor;
at least one signal conditioning circuit so connected to the electrodes of the at least one nerve cuff as to receive signals from the nerve fibers;
at least one stimulation circuit so connected to the electrodes of the at least one nerve cuff as to deliver stimulation pulses to the nerve fibers;
wherein the processor is so configured as to a) selectively activate the at least one signal conditioning circuit in order to detect at least one gait phase transition event and b) activate the at least one stimulation circuit in response to the detection of the at least one gait phase transition event.
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Abstract
A fully implantable nerve stimulation system includes an event-triggered, closed-loop control unit that detects physiological events from nerve signals and delivers stimulation pulses to a nerve to produce a desired physiological response. The stimulation system includes a low-noise, low-power nerve signal amplifier, accelerometers that detect position and a battery powered processor that selectively powers components in the system to detect physiological events and deliver stimulation pulses with a minimum of battery power.
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Citations
81 Claims
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1. A fully implantable nerve stimulation system, comprising:
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at least one nerve cuff so configured as to receiving part of a nerve, the nerve cuff having electrodes therein positioned in the vicinity of nerve fibers; a control unit including; a power source; a processor; at least one signal conditioning circuit so connected to the electrodes of the at least one nerve cuff as to receive signals from the nerve fibers; at least one stimulation circuit so connected to the electrodes of the at least one nerve cuff as to deliver stimulation pulses to the nerve fibers; wherein the processor is so configured as to a) selectively activate the at least one signal conditioning circuit in order to detect at least one gait phase transition event and b) activate the at least one stimulation circuit in response to the detection of the at least one gait phase transition event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A fully implantable nerve stimulation system, comprising:
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at least one nerve cuff so configured as to receiving part of a nerve, the nerve cuff having electrodes therein positioned in the vicinity of nerve fibers; a control unit including; a power source; a processor; at least one signal conditioning circuit so connected to the electrodes of the at least one nerve cuff as to receive signals from the nerve fibers; at least one stimulation circuit so connected to the electrodes of the at least one nerve cuff as to deliver stimulation pulses to the nerve fibers; wherein the processor is so configured as to a) selectively activate the at least one signal conditioning circuit, b) analyse the signals received by the at least one signal conditioning circuit so as to detect either a positive ramp having a duration between a first and a second values and a peak-to-baseline difference greater than a first threshold value or a negative ramp having a duration between a third and a fourth values and a peak-to-baseline difference greater than a second threshold value and c) activate the at least one stimulation circuit in response to the detection of either the positive ramp having a duration between the first and the second values and a peak-to-baseline difference greater than the first threshold value or the negative ramp having a duration between the third and the fourth values and a peak-to-baseline difference greater than the second threshold value. - View Dependent Claims (45, 46)
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47. A fully implantable nerve stimulation system, comprising:
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at least one nerve cuff so configured as to receiving pad of a nerve, the nerve cuff having electrodes therein positioned in the vicinity of nerve fibers; a control unit including; a power source; a processor; a thigh orientation determination circuit producing a signal indicative of an orientation of a patient'"'"'s thigh; at least one signal conditioning circuit so connected to the electrodes of the at least one nerve cuff as to receive signals from the nerve fibers; at least one stimulation circuit so connected to the electrodes of the at least one nerve cuff as to deliver stimulation pulses to the nerve fibers; wherein the processor is so configured as to a) selectively activate the at least one signal conditioning circuit in order to detect a physiological event b) activate the at least one stimulation circuit in response to the detection of the physiological event and c) adjust an output of the at least one stimulation circuit in response to the orientation of the patient'"'"'s thigh. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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Specification