Endothelial cell binding coatings for rapid encapsulation of bioerodable stents
First Claim
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1. A bioerodable device comprising an endothelial cell (EDC) binding agent, wherein the EDC binding agent is selected from the group consisting of collagen type 1, the active fragment of osteopontin, scFV A5, junction membrane protein vascular endothelial (VE)-cadherin, RGD peptide, RGD peptide mimetics, and combinations thereof, andwherein the EDC binding agent is chemically linked to the bioerodable device.
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Abstract
Bioerodable devices such as stents containing one or more endothelial cell binding agents are provided.
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Citations
20 Claims
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1. A bioerodable device comprising an endothelial cell (EDC) binding agent, wherein the EDC binding agent is selected from the group consisting of collagen type 1, the active fragment of osteopontin, scFV A5, junction membrane protein vascular endothelial (VE)-cadherin, RGD peptide, RGD peptide mimetics, and combinations thereof, and
wherein the EDC binding agent is chemically linked to the bioerodable device.
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11. A bioerodable stent comprising an endothelial cell (EDC) binding agent, wherein the EDC binding agent is selected from the group consisting of collagen type 1, the active fragment of osteopontin, scFV A5, junction membrane protein vascular endothelial (VE)-cadherin, RGD peptide, RGD peptide mimetics, and combinations thereof, and
wherein the EDC binding agent is chemically linked to the bioerodable stent.
Specification