Ophthalmic drug delivery system

• US 7,638,137 B2
• Filed: 06/05/2003
• Issued: 12/29/2009
• Est. Priority Date: 06/05/2002
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Gulsen, Derya, Chauhan, Anuj
• Primary Examiner(s): Azpuru; Carlos A.
• Application Number:
  US10/454,836
• Publication Number:
  US 20040096477A1
• Time in Patent Office: 2,399 Days
• Field of Search: None
• US Class Current: 424/429
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/41 having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61K 9/5115 Inorganic compounds
• CPC Class Codes: A61K 9/5138 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/5192 Processes
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration through said contact lens and into the post-lens tear film when said contact lens is placed on the eye.

Claims

1. A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration through said contact lens and into the post-lens tear film when said contact lens is placed on the eye, said nanoparticles being dispersed within said contact lens in an amount such that said lens remains substantially optically transparent.

2. The drug delivery system of claim 1 wherein said amount of nanoparticles is from about 1 to about 5%, by weight, based on the weight of the contact lens.

3. The drug delivery system of claim 1 wherein said contact lens is a soft contact lens.

4. The drug delivery system of claim 3 wherein said contact lens comprises poly 2-hydroxyethylmethacrylate.

5. The drug delivery system of claim 1 wherein said ophthalmic drug is selected from the group consisting of lidocaine, timolol, ciproflaxin, cyclosporin A, and pilocarpine.

6. The drug delivery system of claim 1 wherein said ophthalmic drug is nanoencapsulated with an encapsulation material in an oil-in-water emulsion.

8. The drug delivery system of claim 1 wherein said ophthalmic drug is an antiparisitic drug, a steroid, an antibiotic drug or mixtures thereof.

9. The drug delivery system of claim 6 wherein said encapsulation material is a material selected from the group consisting of biodegradable polycyanoacylate, biodegradable poly(alkylcyanoacrylates), biodegradable calcium phosphate, legumin, polysaccharides grafted with polyesters (amphyphilic copolymers), poly(methylidene malonate), gelatin, poly(E-caprolactone), sodium alginate, agarose hydrogel, PMMA, biotinylated poly(ethylene glycol) conjugated with lactobionic acid, poly(vinyl alcohol) hydrogel, biotinylated pullulan acetate, diblock copolymers and mixtures thereof.

10. The drug delivery system of claim 9 wherein said polycyanoacrulates are selected from the group consisting of polybutylcyanoacrylate, polyhexylcyanoacrylate, polyethylcyano-acrylate, polyisobutylcyanoacrylate, and mixtures thereof.

11. The drug delivery system of claim 6 wherein said nanoparticles are selected from the group consisting of chitosan nanoparticles, human serum albumin nanoparticles;

silica nanospheres;

PEG'"'"'ylated core-shell nanoparticles;

biodegradable PLGA (poly(D,L-lactide-co-glycolide)) particles PLA (poly lactic acid);

PGA, PLG (poly(D, L-glycolide)) polymeric nanoparticles;

biocompatible gliadin nanoparticles;

low pH sensitive PEG stabilized plasmid-lipid nanoparticles, tocopherol derivatives stabilized nano-sized emulsion particles, PLA-PEG nanoparticles, nanoparticles composed of hydrophilic proteins coupled with apolipoprotein E, biodegradable poly (vepsiln-caprolactone) nanoparticles, biotinylated poly(ethylene glycol) conjugated with lactobionic acid, carboxylmethyl dextran magnetic nanoparticles, and mixtures thereof.

7. An article of manufacture comprising packaging material and the ophthalmic drug delivery system contained within said packaging material, said ophthalmic drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration through said contact lens and into the post-lens tear film when said contact lens is placed on the eye, said nanoparticles being dispersed within said contact lens in an amount such that said lens remains substantially optically transparent, wherein said packaging material further includes a label which indicates that said ophthalmic drug delivery system can be used for ameliorating symptoms associated with pathologic conditions of the eye.