Methods of upmodulating an immune response with non-activating forms of B7-4
First Claim
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1. A method for upmodulating an immune response comprising contacting an immune cell expressing PD-1 with an agent that downmodulates signaling via PD-1, wherein the agent comprises a non-activating form of B7-4 of SEQ ID NO:
- 2 or SEQ ID NO;
4, or extracellular or variable region-like domains thereof, to thereby upmodulate the immune response.
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Abstract
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
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7 Claims
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1. A method for upmodulating an immune response comprising contacting an immune cell expressing PD-1 with an agent that downmodulates signaling via PD-1, wherein the agent comprises a non-activating form of B7-4 of SEQ ID NO:
- 2 or SEQ ID NO;
4, or extracellular or variable region-like domains thereof, to thereby upmodulate the immune response. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 2 or SEQ ID NO;
Specification