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Methods of upmodulating an immune response with non-activating forms of B7-4

  • US 7,638,492 B2
  • Filed: 08/31/2006
  • Issued: 12/29/2009
  • Est. Priority Date: 08/23/1999
  • Status: Expired due to Fees
First Claim
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1. A method for upmodulating an immune response comprising contacting an immune cell expressing PD-1 with an agent that downmodulates signaling via PD-1, wherein the agent comprises a non-activating form of B7-4 of SEQ ID NO:

  • 2 or SEQ ID NO;

    4, or extracellular or variable region-like domains thereof, to thereby upmodulate the immune response.

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