Headstage

• US 7,639,983 B2
• Filed: 02/19/2008
• Issued: 12/29/2009
• Est. Priority Date: 10/23/2004
• Status: Expired due to Fees

• Current Assignee: Triangle BioSystems, Inc. (Harvard Bioscience, Inc.)
• Original Assignee: Triangle BioSystems, Inc. (Harvard Bioscience, Inc.)
• Inventors: Morizio, James C, Go, Vinson L, Irazoqui-Pastor, Pedro, Parmentier, Jack D
• Primary Examiner(s): Jackson; Blane J
• Application Number:
  US12/033,220
• Publication Number:
  US 20080146960A1
• Time in Patent Office: 679 Days
• Field of Search: 455/91, 455/95, 455/100, 455/103, 455/120, 455/127.2, 455/127.3, 455/128, 455/129, 330/306, 600/546
• US Class Current: 455/41.2
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/31 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: G06N 3/061 using biological neurons, e.g. biological neurons connected to an integrated circuit
• CPC Class Codes: H04B 1/04 Circuits

Abstract

A headstage for a Neural Data Acquisition System is shown and described. In one embodiment, the headstage includes at least one Input Pre-amplifier, and a multiplexer (MUX) for multiplexing at least one channel. In one embodiment, the input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode.

Claims

1. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier;

a multiplexer (MUX) for multiplexing at least one channel; and

an RF Modulator comprising a voltage control oscillator (VCO),

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode, and

wherein input impedance of the RF Modulator is configured to allow the MUX to drive the RF stare directly.

2. The headstage of claim 1, wherein the at least one transistor is an on-chip resistor.

3. The headstage of claim 1, wherein the at least one on-chip transistor includes at least two dual stacked transistors.

4. The headstage of claim 1, wherein the at least one transistor includes at least one metal-oxide-semiconductor field-effect transistor (MOSFET).

5. The headstage of claim 1, wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

6. The headstage of claim 1, wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor.

7. The headstage of claim 1, wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

8. The headstage of claim 1, wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.

9. The headstage of claim 1, further including a transmitting antenna configured to transmit at a range of about less than 10 meters, thereby permitting denser use.

10. The headstage of claim 1, further including a power supply.

11. The headstage of claim 1, further including a clock.

12. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier;

a multiplexer (MUX) for multiplexing at least one channel, wherein an input filter of the Input Pre-amplifier is tuned by at least one resistor; and

an RF Modulator comprising a voltage control oscillator (VCO), wherein input impedance of the RE Modulator is configured to allow the MUX to drive the RF stage directly.

13. The headstage of claim 12, wherein the at least one resistor is a transistor configured to operate as a resistor.

14. The headstage of claim 12, wherein the at least one resistor is an on-chip resistor.

15. The headstage of claim 14, wherein the at least one on-chip resistor includes at least two dual stacked resistors.

16. The headstage of claim 12, wherein the at least one resistor includes a transistor operating in sub-threshold mode.

17. The headstage of claim 12, wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

18. The headstage of claim 12, wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

19. The headstage of claim 12, wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.

20. The headstage of claim 12, wherein the MUX is configured to sample at greater than 50 kHz per channel and is configured to multiplex from a number of channels selected from at least 16 channels, at least 32 channels, at least 100 channels, and at least 250 channels.

21. The headstage of claim 12, further including a transmitting antenna configured to transmit at a range of about less than 10 meters, thereby permitting denser use.

22. The headstage of claim 12, further including a power supply and a clock.

23. A method of neural data monitoring, comprising the steps of:

implanting electrodes into the brain of a specimen;

connecting the electrode connector of a headstage to the implanted electrodes, wherein the headstage includes an Input Pre-amplifier, a multiplexer (MUX) for multiplexing at least one channel,

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode,

wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor; and

transmitting neural data via a transmitting antenna.

24. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier; and

a multiplexer (MUX) for multiplexing at least one channel,

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of at least one transistor operating in sub-threshold mode,

wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and

wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor.

25. The headstage of claim 24, wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

26. The headstage of claim 24, wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

27. The headstage of claim 24, wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.