Monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants, and corresponding method

• US 7,640,816 B2
• Filed: 08/06/2005
• Issued: 01/05/2010
• Est. Priority Date: 08/14/2004
• Status: Expired due to Fees

• Current Assignee: LTS Lohmann Therapie-Systeme AG
• Original Assignee: LTS Lohmann Therapie-Systeme AG
• Inventors: Horstmann, Michael, Schmitz, Christoph, Sameti, Mohammad, Przybylla, Yves-Thorsten, Schutz, Christina
• Primary Examiner(s): Williams; Hezron
• Assistant Examiner(s): DEVITO, ALEX T
• Application Number:
  US11/659,072
• Publication Number:
  US 20070289360A1
• Time in Patent Office: 1,613 Days
• Field of Search: 73/232.5, 73/310.5, 738/632.1, 422/57, 422/68.1, 422/100, 428/173
• US Class Current: 73/863.21
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: G01N 1/2273 Atmospheric sampling
• CPC Class Codes: G01N 2001/2223 aerosol sampling devices
• CPC Class Codes: G01N 2001/2276 Personal monitors
• CPC Class Codes: G01N 2001/2833 Collecting samples on a sticky, tacky, adhesive surface
• CPC Class Codes: G01N 2013/003 Diffusion; diffusivity between liquids

Abstract

Disclosed is a monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants. The inventive monitoring system generally includes at least one diffusion collector and/or an equilibrium diffuser. The diffusion collector is provided with at least three layers, i.e. an adhesive layer that is in direct contact with the skin of a living being, a barrier layer, and a collecting layer on the exterior face of the monitoring system. The equilibrium diffuser includes an adhesive layer and a collecting layer. The collecting layers and the adhesive layers of the two components of the monitoring system are preferably made of the same material and have the same dimensions.

Claims

1. A dermal uptake monitoring system for collecting and rediffusing environmental contaminants present in ambient air, wherein said monitoring system can be arranged flat on the skin of a living being and comprises at least one diffusion collector and at least one equilibrium diffuser, wherein

(i) said diffusion collector permits rediffusion of said environmental contaminants into the ambient air and prevents diffusion of the environmental contaminants into the skin and

(ii) said equilibrium diffuser permits both rediffusion of said environmental contaminants into the ambient air and transdermal diffusion into the skin.

2. The monitoring system as claimed in claim 1, wherein the diffusion collector comprises at least three layers, (i) a layer directed toward the skin on a living being and adhering to the skin, (ii) a barrier layer preventing diffusion of the environmental contaminants into the skin, and (iii) a collecting layer taking up the environmental contaminants.

3. The monitoring system as claimed in claim 1, wherein the equilibrium diffuser comprises at least two layers, (i) a layer bearing on the skin on a living being and adhering to the skin, and (ii) a collecting layer taking up the environmental contaminants said equilibrium diffuser permitting transdermal rediffusion of said environmental contaminants into the skin.

4. The monitoring system as claimed in claim 2, wherein the collecting layer is comprised of at least one polymer material suitable for transdermal purposes.

5. The monitoring system as claimed in claim 4, wherein said polymer material further comprises porous, absorbent materials to increase the solubility and the absorption of organic environmental contaminants.

6. The monitoring system as claimed in claim 4, wherein the polymer material(s) consists of silicone copolymers, polyisobutylene, acrylate copolymers, and/or styrene-isoprene copolymers.

7. The monitoring system as claimed in claim 5, wherein the porous, absorbent materials are selected from activated charcoal, bentonite, silicon dioxide, and/or synthesized polymers with specific affinities for certain organic trace elements.

8. The monitoring system as claimed in claim 2, wherein the adhesive layer contains silicone copolymers, polyacrylates, polyisobutylene or mixtures thereof.

9. The monitoring system as claimed in claim 2, wherein the barrier layer comprises pure metal, polyethylene terephthalate, acrylonitrile copolymer or polytetrafluoroethylene.

10. The monitoring system as claimed in claim 9, wherein the metal is aluminum, silver or gold.

11. The monitoring system as claimed in claim 2, wherein both the diffusion collector and also the equilibrium diffuser contain one or more additional layers as barrier layer(s) for certain environmental contaminants, and/or nonstick layers for textiles, plastics, or leather.

12. The monitoring system as claimed in claim 2, wherein the diffusion collector and the equilibrium diffuser each have collecting layers and adhesive layers of the same material.

13. The monitoring system as claimed in claim 2, wherein the collecting layers and the adhesive layers of the diffusion collector and the equilibrium diffuser each have the same dimensions.

14. The monitoring system as claimed in claim 2, wherein the adhesive layer has a thickness of 5 to 200 μ

m.

15. The monitoring system as claimed in claim 2, wherein the diffusion collector consists of a collecting layer, a barrier layer and an adhesive layer and the diffusion collector has a thickness of 7 to 305 μ

m.

16. The monitoring system as claimed in claim 1, wherein the living being is a human or an animal.

17. The monitoring system as claimed in claim 14, wherein the adhesive layer has a thickness of 5 to 100 μ

m.

19. A monitoring system as claimed in claim 1, wherein said system further comprises a means for analytical determination of individual environmental contaminants within said diffusion collector and said equilibrium diffuser.

18. An equilibrium diffuser for transdermally re-diffusing air contaminants comprising (i) an adhesive layer which can adhere to skin, and (ii) a collecting layer taking up air contaminants, said collecting layer comprising polymer(s) consisting of silicone copolymers, polyisobutylene, acrylate copolymers, or styrene-isoprene copolymers, wherein said equilibrium diffuser does not include a barrier layer thereby permitting transdermal rediffusion.