Integrated blood treatment module having a support element

• US 7,641,626 B2
• Filed: 06/06/2007
• Issued: 01/05/2010
• Est. Priority Date: 02/07/2003
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Zaccarelli, Massimo, Aberkane, Aziz, Duchamp, Jacques, Tonelli, Claudio, Meyssonnier, Gabriel, Chevallet, Jacques, Pouchoulin, Dominique, Baraldi, Vincenzo, Delnevo, Annalisa, Ribolzi, Francesco
• Primary Examiner(s): Deak; Leslie R
• Application Number:
  US11/808,069
• Publication Number:
  US 20070293803A1
• Time in Patent Office: 944 Days
• Field of Search: 604/4.01, 604/5.01, 604/5.04, 604/6.09, 604/6.11, 604/6.16, 210645-647, 210/90, 210/525, 210/321.71, 210/232, 210/240, 422/44, 417/477.2, 417/237, 417/439, 417/472, 417/474, 248/274.1, 312/209
• US Class Current: 604/4.01
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1643 with weighing of fresh and used dialysis fluid
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3413 Diafiltration
• CPC Class Codes: A61M 1/3434 with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3451 the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 1/3465 using dialysate as substitution fluid
• CPC Class Codes: A61M 2205/126 with incorporated membrane filters
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: Y10T 137/877 With flow control means for branched passages

Abstract

The invention relates to support element (4) comprising a main body (6) having a front wall (25) and a peripheral wall (32) projecting away from the front wall. The front wall and the peripheral wall define a housing compartment (33) designed to receive a fluid distribution circuitry cooperating with a treatment unit for defining an integrated blood treatment module.

Claims

1. An integrated fluid treatment module comprising:

a support element comprising a main body having a front wall and at least a peripheral wall projecting away from said front wall, said front wall and said peripheral wall defining a housing compartment, said front wall being delimited by first and second opposite longer sides with a basically rectilinear development, each of said first and second opposite longer sides having first and second curved portions forming a cavity facing a respective opposite longer side, said front wall being further delimited by first and second opposite shorter sides with a basically rectilinear development, at least one of said first and second opposite shorter sides having a third curved portion configured between first and second rectilinear lengths, a cavity formed by said third curved portion facing the other of said first and second opposite shorter sides, the support element further comprising at least one pair of tube engagement connectors, each of said at least one pair of tube engagement connectors being placed on opposite ends of each of said first, second, and third curved portions;

at least one blood treatment unit engaged to the support element; and

a fluid distribution circuitry associated with the support element and cooperating with the treatment unit.

2. A module according to claim 1, wherein the fluid distribution circuitry comprises at least a blood line having a blood withdrawal branch and a blood return branch.

3. A module according to claim 2, wherein the blood line is secured to the support element on one of said first and second opposite shorter sides having the curved portion.

4. A module according to claim 3, wherein the blood line is secured to the support element so as to define at least one tube length arranged as a U with respect to said support element, the tube length being designed to cooperate with a respective pump.

5. A module according to claim 4, wherein the U-shaped tube length extends inside the peripheral wall of the support element.

6. A module according to claim 4, wherein positioning projections act on the U-shaped tube length of the blood line to keep said U-shaped tube length in a constant position.

7. A module according to claim 4, wherein the tube length of the blood line secured to the support element is defined by the withdrawal branch.

8. A module according to claim 1, wherein the fluid distribution circuit further comprises at least an intake line for a fresh dialysis liquid.

9. A module according to claim 8, wherein the intake line for fresh dialysis liquid is fastened to the support element on one of said first opposite longer sides.

10. A module according to claim 9, wherein the intake line for fresh dialysis liquid is secured to the support element so as to define at least a tube length arranged as a U with respect to said support element, said tube length being designed to cooperate with a respective pump.

11. A module according to claim 9, wherein the U-shaped tube length extends inside the peripheral wall of the support element.

12. A module according to claim 8, wherein the intake line is secured to the main body on the support element, at least an inlet length of the intake line being engaged into a main seat of a positioning fin and to a respective engagement connector, at least an outlet length of the intake line being engaged into a main seat of the positioning fin and to a respective engagement connector.

13. A module according to claim 12, wherein the inlet and outlet lengths engaged to the respective engagement connectors are placed in rectilinear arrangement, said inlet and outlet lengths being parallel to one another.

14. A module according to claim 12, wherein the outlet length branches into an intake branch designed to convey fluid to the blood treatment unit, and into an infusion branch designed to convey fluid into the blood line.

15. A module according to claim 14, wherein the branching of the outlet length into said infusion branch and said intake branch is defined on an engagement connector.

16. A module according to claim 14, wherein the infusion branch is secured to an auxiliary seat and to another main seat.

17. A module according to claim 14, wherein the infusion branch and the intake branch, when engaged to the support element, are placed in rectilinear arrangement, said infusion branch and said intake branch being parallel to one another.

18. A module according to claim 1, wherein the fluid distribution circuitry comprises at least an infusion line.

19. A module according to claim 18, wherein the infusion line is secured to the support element on one of said first and second opposite longer sides.

20. A module according to claim 19, wherein the infusion line is fastened to the support element so as to define at least a tube length arranged as a U with respect to said support element, said tube length being designed to cooperate, when in use, with a respective pump.

21. A module according to claim 20, wherein the tube length arranged as a U extends inside the peripheral wall of the support element.

22. A module according to claim 18, wherein the infusion line is secured to the main body on the support element, at least an outlet length of the infusion line being engaged into a main seat of a positioning fin and to a respective engagement connector.

23. A module according to claim 22, wherein the outlet length branches into a pre-infusion branch designed to convey the fluid to a withdrawal branch of the blood line, and into a post-infusion branch designed to convey the fluid to a blood return branch of the blood line.

24. A module according to claim 23, wherein the branching of the outlet length into said pre-infusion branch and said post-infusion branch is defined on an engagement connector.

25. A module according to claim 23, wherein the pre-infusion branch is secured to an auxiliary seat and to another main seat of the positioning fin.

26. A module according to claim 23, wherein the pre-infusion branch and the post-infusion branch, when engaged to the support element, are placed in rectilinear arrangement, said pre-infusion branch and said post-infusion branch being parallel to one another.

27. A module according to claim 1, wherein the fluid distribution circuit comprises at least a discharge line.

28. A module according to claim 27, wherein the discharge line conveys a waste fluid, said discharge line being is secured to the support element on one of said first and second opposite longer sides.

29. A module according to claim 28, wherein said discharge line is secured to the support element so as to define at least a tube length arranged as a U with respect to said support element, said tube length being designed to cooperate, when in use, with a respective pump.

30. A module according to claim 29, wherein the U-shaped tube length extends inside the peripheral wall of the support element.

31. A module according to claim 27, wherein the discharge line is fastened to the main body on the opposite side with respect to the support element, an inlet length and an outlet length of the discharge line being engaged into corresponding engagement connectors.

32. A module according to claim 1, wherein the fluid distribution circuit comprises at least an auxiliary pre-infusion line.

33. A module according to claim 32, wherein the auxiliary pre-infusion line is fastened to the support element on one of said first and second opposite longer sides.

34. A module according to claim 33, wherein said pre-infusion line is secured to the support element so as to define at least one tube length arranged as a U with respect to said support element, said tube length being designed to cooperate, when in use, with a respective pump.

35. A module according to claim 34, wherein the U-shaped tube length extends inside the peripheral wall of the support element.

36. A module according to claim 32, wherein the auxiliary pre-infusion line is fastened to the main body on the opposite side with respect to the support element, at least an inlet length and at least an outlet length of the auxiliary pre-infusion line being engaged into corresponding engagement connectors.

37. A module according to claim 4, wherein said at least one U-shaped tube length is smaller than or the same as (π

R+2R), where R is the respective radius of curvature of the tube length.

38. An integrated module according to claim 4, wherein the fluid distribution circuit comprises further fluid lines secured to the support element, each further fluid line defining at least a tube length arranged as a U with respect to said support element, each tube length being designed to cooperate, when in use, with a respective pump, the support element having a first zone to which a portion of the blood line is fastened and at least a second zone opposite said first zone, the further fluid lines being all secured on said second zone.

39. A Module according to claim 38, wherein the U-shaped tube length of the blood line is longer than the tube lengths defined by the further fluid lines.

40. A module according to claim 38, wherein the U-shaped tube length of the blood line has a greater radius of curvature than the tube lengths defined by the further fluid lines.

41. A module according to claim 38, wherein said second zone comprises at least first and second half-parts placed side by side, at least a tube length of a discharge line of a waste fluid being fastened to the second half-part.

42. A module according to claim 38, wherein said second zone comprises at least first and second half-parts placed side by side, at least a tube length of an intake line for fresh liquid being fastened to the first half-part.

43. A module according to claim 38, wherein said second zone comprises at least first and second half-parts placed side by side, at least a tube length of an infusion line being fastened to the first half-part.

44. A module according to claim 38, wherein said second zone comprises at least first and second half-parts placed side by side, at least a tube length of an auxiliary pre-infusion line being fastened to the second half-part.

45. A module according to claim 38, wherein the first zone is partly delimited by at least one of said first and second opposite shorter sides having the curved portion and by a portion of the first opposite longer side beside said at least one of said first and second opposite shorter sides having the curved portion.

46. A module according to claim 38, wherein the second zone is partly delimited by one of said first and second opposite shorter sides without the curved portion and by a portion of the first opposite longer side beside said at least one of said first and second opposite shorter sides without the curved portion.

47. A module according to claim 38, wherein when the module is associated to an extracorporeal blood treatment machine, the first zone of the support element is placed below the second zone of the support element.

48. A module according to claim 41, wherein when the module is associated to an extracorporeal blood treatment machine, the first and second half-part of the second zone of the support element are placed side by side.

49. A module according to claim 38, wherein one of said first and second opposite shorter sides without the curved portion has no tube length directly fastened thereto.

50. A module according to claim 41, wherein the first and second half-parts are specularly symmetrical with respect to a longitudinal axis of the main body.

51. A module according to claim 1, wherein said treatment unit is fastened to the main body on at least a pair of connectors.

52. A module according to claim 51, characterized in that said pair of connectors is placed between counter-connectors and a portion of the fluid distribution circuit.

53. A module according to claim 1, in which said treatment unit comprises:

a housing body;

at least a semipermeable membrane operating inside the housing body defining a first and a second chamber;

a first and a second counter-connector associated to the housing body and fastened to respective connectors associated to the main body, at least one of said first and second counter-connector being put into fluid communication with the second chamber of the treatment unit and with respective first end portions of said respective connectors;

at least an access door to said first chamber; and

at least an exit door from said first chamber.

54. A module according to claim 53, wherein the fluid distribution circuit comprises at least a discharge line for a waste fluid, said discharge line being in communication with a second end portion of one of said respective connectors.

55. A module according to claim 54, wherein the fluid distribution circuit comprises at least an intake line for fresh dialysis liquid, said intake line being in communication with the second end portion of one of said respective connectors.

56. A module according to claim 53, in which the fluid distribution circuit comprises at least a blood line having a blood withdrawal branch, said blood line being in communication with the access door to the first chamber, and at least a blood return line, said blood return line being in communication with the exit door from the first chamber.

57. A module according to claim 38, wherein the blood line has tubes comprising a different material with respect to the further fluid lines.