Portable sample analyzer with removable cartridge

• US 7,641,856 B2
• Filed: 05/12/2005
• Issued: 01/05/2010
• Est. Priority Date: 05/14/2004
• Status: Active Grant

• Current Assignee: Honeywell International Inc.
• Original Assignee: Honeywell International Inc.
• Inventors: Padmanabhan, Aravind, Fritz, Bernard S., Cabuz, Cleopatra, Cox, James A.
• Primary Examiner(s): Warden; Jill
• Assistant Examiner(s): JARRETT, LORE RAMILLANO
• Application Number:
  US10/908,461
• Publication Number:
  US 20050255001A1
• Time in Patent Office: 1,699 Days
• Field of Search: 422/73, 422/100, 356/39, 436/10, 435/7.24, 738/655
• US Class Current: 422/73
• CPC Class Codes: B01L 2200/0636 Focussing flows, e.g. to laminate flows
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502776 specially adapted for focusing or laminating flows
• CPC Class Codes: G01N 15/1404 Handling flow, e.g. hydrodynamic focusing
• CPC Class Codes: G01N 2015/1413 Hydrodynamic focussing
• CPC Class Codes: G01N 2015/1486 Counting the particles
• CPC Class Codes: Y10T 436/101666 Particle count or volume standard or control [e.g., platelet count standards, etc.]

Abstract

A sample analyzer with a removable and/or disposable cartridge for use at the point of care of a patient such as in a doctor'"'"'s office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

Claims

1. A blood sample analysis system, comprising:

a disposable fluidic cartridge configured to receive and at least partially process a blood sample;

the disposable fluidic cartridge includes a white blood cell measurement channel and a red blood cell measurement channel;

the white blood cell measurement channel in the disposable fluidic cartridge includes a white blood cell intersecting region configured to hydrodynamically focus a sample along the white blood cell measurement channel and an optical light scattering white blood cell measurement region that includes a white blood cell optical window region used in measuring selected characteristics of white blood cells passing by the white blood cell optical window region of the white blood cell measurement channel;

the red blood cell measurement channel in the disposable fluidic cartridge includes a red blood cell intersecting region configured to hydrodynamically focus a sample along the red blood cell measurement channel and an optical light scattering red blood cell measurement region that includes a red blood cell optical window region used in measuring selected characteristics of red blood cells passing by the red blood cell optical window region of the red blood cell measurement channel; and

the disposable fluidic cartridge further including fluid directing means for directing flow of a first part of the blood sample to the white blood cell measurement channel and a second part of the blood sample to the red blood cell measurement; and

an analyzer configured to receive the disposable fluidic cartridge;

the analyzer comprises at least one light source and at least one detector positioned to align with the red blood cell optical window region and at least one light source and at least one detector positioned to align with the white blood cell optical window region, and a processor for determining two or more of the selected characteristics without further interaction from a user, and for outputting to the user at least one blood analysis result that is based on at least one of the two or more of the selected characteristics.

2. The blood sample analysis system of claim 1, wherein the at least one blood analysis result includes a qualitative indication to the user that indicates if one or more of the selected characteristics are within one or more expected ranges of values.

3. The blood sample analysis system of claim 1, wherein the processor outputs the at least one blood analysis result after the analyzer is activated by a user without further interaction from the user.