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Method for making heteromultimeric polypeptides

  • US 7,642,228 B2
  • Filed: 12/07/2001
  • Issued: 01/05/2010
  • Est. Priority Date: 03/01/1995
  • Status: Expired due to Fees
First Claim
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1. An isolated heteromultimer comprising at least a first polypeptide and a second polypeptide, whereinthe first polypeptide is associated with the second polypeptide via an interface, said interface having introduced therein at least one protuberance or cavity such that:

  • (a) the interface of the first polypeptide comprises a protuberance that is positionable in a cavity in the iterface of the second polypeptide and/or(b) the interface of the first polypeptide comprises a cavity that accommodates a protuberance of the second polypepetide, such that a greater ratio of heteromultimer;

    homomultimer forms than for a multitimer having a wild-type interface, and2) polypeptide interface via a CH3 constant damain of an antibody.

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