Method and system for evaluating delivered dose

• US 7,643,661 B2
• Filed: 07/21/2006
• Issued: 01/05/2010
• Est. Priority Date: 07/22/2005
• Status: Active Grant

• Current Assignee: TomoTherapy Incorporated (Accuray Incorporated)
• Original Assignee: TOMO Therapy Incorporated
• Inventors: Haimerl, Jason, Kapatoes, Jeffrey M., Ruchala, Kenneth J., Lu, Weiguo, Schnarr, Eric, Mackie, Thomas R., Olivera, Gustavo H.
• Primary Examiner(s): Strege; John B
• Application Number:
  US11/459,055
• Publication Number:
  US 20070041494A1
• Time in Patent Office: 1,264 Days
• Field of Search: 382/128, 382/130, 382/131, 382/132, 382/256, 382/257, 382/294
• US Class Current: 382/128
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1065 Beam adjustment
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

A system and method of evaluating a radiation dose delivered to a patient receiving radiation therapy. The method includes the acts of generating a time-based series of patient images, collecting a time-based series of data indicating patient motion, and evaluating a radiation dose delivered to the patient based upon the time-based series of patient images and the time-based series of data.

Claims

1. A method of evaluating a radiation dose delivered to a patient receiving radiation therapy, the method comprising using a computer to carry out the steps of:

generating a 4D image set of the patient;

collecting a time-based series of data indicating patient motion;

evaluating a therapeutic radiation dose delivered to the patient based upon the 4D image set and the time-based series of data; and

acquiring radiation delivery machine parameter data to validate that the therapeutic radiation dose delivered to the patient was reasonable.

2. A method as set forth in claim 1 and further comprising correlating the patient motion data with the image data.

3. A method as set forth in claim 1 wherein the 4D image set includes phases, and wherein the method further comprises the step of calculating the dose delivered in each phase.

4. A method as set forth in claim 1 and further comprising calculating a cumulative dose delivered to the patient based on the 4D image set.

5. A method as set forth in claim 4 and further comprising using deformable registration to relate the images.

6. A method as set forth in claim 1 and further comprising acquiring data relating to clinical dose delivered and patient effects, and applying a biological model that relates the clinical dose to the patient effects.

7. A method as set forth in claim 1 wherein the 4D image set is generated by one of 4D CT, 4D MRI, and 4D PET.

8. A method as set forth in claim 1 wherein the time-based series of patient motion data originated from one of an on-board detector and an external device.

9. A method as set forth in claim 8 wherein the external device is one of a camera, a spirometer, and a chest band.

10. A system for determining a radiation dose delivered to a patient, the system comprising:

a radiation therapy treatment device including a computer processor, the radiation therapy treatment device operable to deliver radiation to a patient according to a treatment plan; and

a software program stored in a computer readable medium accessible by the computer processor, the software being operable to receive a 4D image set of the patient, input a time-based series of data indicating patient motion, evaluate a therapeutic radiation dose delivered to the patient based upon the 4D image set and the time-based series of data, and acquire radiation delivery machine parameter data to validate that the therapeutic radiation dose delivered to the patient was reasonable.

11. A system as set forth in claim 10 further comprising a motion detection system, and wherein the motion detection system is operable to detect the motion of the patient and communicate with the computer processor.

12. A system as set forth in claim 10 wherein the 4D image set includes phases, and wherein the software program is further operable to evaluate the radiation dose delivered to the patient for each time in one or more phases of the image best representing the patient position.

13. A system as set forth in claim 10 wherein the software program is operable to calculate a cumulative radiation dose delivered to the patient based on the 4D image set.

14. A system as set forth in claim 13 wherein the software program is further operable to relate the 4D image set using deformable registration.

15. A method of evaluating a radiation dose delivered to a patient receiving radiation therapy, the method comprising using a computer to carry out the steps of:

generating a treatment plan for the patient;

initiating radiation therapy treatment according to the treatment plan;

generating 4D CT images of the patient during delivery of the radiation therapy treatment; and

calculating a radiation dose delivered to the patient based on each of the 4D CT images.

16. A method as set forth in claim 15 wherein the 4D CT images includes phases, and wherein calculating the radiation dose of the 4D CT images includes calculating the radiation dose delivered in each phase.

17. A method as set forth in claim 15 and further comprising calculating a cumulative dose delivered to the patient based on the 4D CT images.

18. A method as set forth in claim 17 and further comprising using deformable registration to relate the 4D CT images.

19. A method of evaluating a radiation dose delivered to a patient receiving radiation therapy, the method comprising using a computer to carry out the steps of:

generating a treatment plan for the patient, the treatment plan including a reference image;

acquiring a 4D CT image from an imaging device positioned on a radiation therapy treatment system;

calculating a radiation dose on the 4D CT image; and

relating the 4D CT image to the reference image using deformation.

20. A method as set forth in claim 19 wherein the reference image is one of a planning image and a pre-treatment image.

21. A method as set forth in claim 19 and further comprising acquiring patient motion data and correlating the patient motion data with the 4D CT image data.

22. A method as set forth in claim 19 wherein the 4D CT images includes phases, and wherein calculating the radiation dose of the 4D CT images includes calculating the radiation dose delivered in each phase.

23. A method as set forth in claim 19 and further comprising calculating a cumulative dose delivered to the patient based on the 4D CT image.

24. A method as set forth in claim 23 and further comprising using deformable registration to relate the images.

25. A method as set forth in claim 19 wherein the treatment plan can comprise a plurality of sub-plans.

26. A method as set forth in claim 25 wherein the sub-plans are one of a prospective plan and a retrospective plan.

27. A method as set forth in claim 25 wherein the sub-plans are one of a gating plan, a breath hold plan, a free-breathing plan, a three-dimensional plan, and a breathing synchronized delivery plan.

28. A method as set forth in claim 19 and further comprising modifying the 4D CT image based at least in part on the combination of the deformation and the reference image.

29. A method as set forth in claim 19 and further comprising modifying the reference image based upon the combination of the 4D CT image and the deformation.

30. A method of evaluating a radiation dose to be delivered to a patient, the method comprising using a computer to carry out the steps of:

generating a time-based series of three-dimensional patient images;

retrieving a simulated time-based series of data indicating patient motion; and

evaluating a therapeutic radiation dose that would be delivered to the patient based upon the time-based series of three-dimensional patient images and the simulated time-based series of data.