System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device

• US 7,643,872 B2
• Filed: 03/15/2007
• Issued: 01/05/2010
• Est. Priority Date: 06/24/2003
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Kil, Jong, Chitre, Yougandh, Min, Xiaoyi, Bornzin, Gene A., Snell, Jeffery D.
• Primary Examiner(s): Evanisko; George R
• Assistant Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US11/686,784
• Publication Number:
  US 20070156056A1
• Time in Patent Office: 1,027 Days
• Field of Search: 607/17, 607/25, 607/26, 600/515, 600/517, 600/518
• US Class Current: 600/517
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/355 Detecting T-waves
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

Claims

1. In an implantable medical device for implant within a patient, a system comprising:

a T-wave detection subsystem operative to detect individual T-waves;

a T-wave energy integration subsystem operative to determine a total energy for each of the individual T-waves; and

a cardiac ischemia detection subsystem operative to;

a) calculate a running average of the total energies of the detected T-waves;

b) calculate the difference between the total energy of a last detected T-wave and the running average;

c) compare the energy difference to a predetermined energy threshold value;

repeat a), b) and c) for a plurality of cardiac beats; and

detect cardiac ischemia when the difference exceeds the predetermined energy threshold value for a predetermined number of cardiac beats.

2. The system of claim 1 wherein the detection subsystem is operative to detect termination of an episode of ischemia when the energy difference between the total energy and the running average of the total energies is less than the predetermined energy threshold value for a predetermined number of cardiac beats.

3. The system of claim 1 further comprising a T-wave slope determination subsystem operative to determine a maximum slope of individual T-waves and wherein the cardiac ischemia detection subsystem is operative to:

d) calculate a running average of the maximum slopes of the detected T-waves;

e) calculate the difference between the maximum slope of a last detected T-wave and the slope running average;

f) compare the slope difference to a predetermined slope threshold value;

repeat d), e) and f) for a plurality of cardiac beats; and

detect cardiac ischemia when the slope difference exceeds the predetermined slope threshold value for a predetermined number of cardiac beats.

4. The system of claim 3 wherein the detection subsystem is operative to detect termination of an episode of ischemia when the difference between the maximum slope and the running average slope is less than the slope threshold value for a predetermined number of cardiac beats.

5. A method comprising:

detecting a plurality of individual T-waves;

calculating a total energy for each of the individual T-waves;

a) calculating a running average of the total energies of the detected T-waves;

b) calculating the difference between the total energy of a last detected T-wave and the running average;

c) comparing the energy difference to a predetermined energy threshold value;

repeating a), b) and c) for a plurality of cardiac beats; and

indicating cardiac ischemia when the energy difference exceeds the predetermined energy threshold value for a predetermined number of cardiac beats.

6. The method of claim 5 wherein upon detection of ischemia:

determining the difference between the total energy and the average of the total energies;

comparing the energy difference to the energy threshold value; and

indicating termination of ischemia when the energy difference is less than the energy threshold value for a predetermined number of cardiac beats.

7. The method of claim 5 wherein detecting a plurality of individual T-waves comprises detecting a plurality of T-waves arising from sinus ventricular beats and the predetermined energy threshold value is a predetermined sinus-beat energy threshold.

8. The method of claim 5 wherein detecting a plurality of individual T-waves comprises detecting a plurality of T-waves arising from paced ventricular beats and the predetermined energy threshold value is a predetermined paced-beat energy threshold.

9. The method of claim 5 further comprising:

calculating a maximum slope for the individual T-waves;

d) calculating a running average of the maximum slopes of the detected T-waves;

e) calculating the difference between the maximum slope of a last detected T-wave and the slope running average;

f) comparing the difference to a predetermined slope threshold value;

repeating d), e) and f) for a plurality of cardiac beats; and

indicating cardiac ischemia when the slope difference exceeds the predetermined slope threshold value for a predetermined number of cardiac beats.

10. The method of claim 9 further comprising indicating termination of an episode of ischemia when the difference between a maximum slope and an running average maximum slope is less than the predetermined slope threshold value for a predetermined number of cardiac beats.