Chronic performance control system for rotodynamic blood pumps

• US 7,645,225 B2
• Filed: 03/19/2001
• Issued: 01/12/2010
• Est. Priority Date: 03/27/2000
• Status: Expired due to Fees

• Current Assignee: Alexander Massiello, Alexander Medvedev, Leonard A.R. Golding
• Original Assignee: Alexander Massiello, Alexander Medvedev, Leonard A.R. Golding
• Inventors: Medvedev, Alexander, Golding, Leonard A. R., Massiello, Alexander
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Stice; Paula J
• Application Number:
  US10/333,759
• Publication Number:
  US 20040152944A1
• Time in Patent Office: 3,221 Days
• Field of Search: 600/16, 600/17, 623/3.1, 623/3.28, 417/44.1, 417/44.11, 318/432, 318/438
• US Class Current: 600/17
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3365 Rotational speed
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/221 the blood flow through the rotating member having both radial and axial components, e.g. mixed flow pumps
• CPC Class Codes: A61M 60/232 Centrifugal pumps
• CPC Class Codes: A61M 60/237 the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
• CPC Class Codes: A61M 60/411 generated by an electromotor
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed

Abstract

In a left ventricular assist device (LVAD) a rotodynamic blood pump (10) is powered by a brushless DC motor (12). A power supply (14) supplies power to the motor (12). Three feedback channels, one for each of voltage, current, and motor speed lead to a microcontroller or microprocessor (18). The three feedback waveforms are analyzed, and from these waveforms, motor input power, patient heart rate, current pump flow rate, and systemic pressure are determined. The microprocessor (18) then calculates a desired flow rate proportional to the patient heart rate. The microprocessor communicates a new power output to a commutation circuit (16), which regulates power to the motor (12). The pump (10) also includes safety checks that are prioritized over desired pump flow. These include prevention of ventricular suction, low pulsatility, minimum and maximum pump speed, minimum speed-relative pump flow, minimum absolute pump flow, minimum and maximum motor input power.

Claims

1. A cardiac assist apparatus comprising:

a blood pump;

a drive unit that drives the blood pump;

a power supply that supplies power to the drive unit;

a frequency sensor that senses a rotational speed of the blood pump;

a current sensor that senses an average direct current waveform of the drive unit;

a power supply voltage sensor that senses a power supply voltage; and

a blood pump controller that;

(i) receives data from the frequency sensor, current sensor, and the power supply voltage sensor;

(ii) passively determines, from said data, a physiologic status of a patient without affecting one or more of the following;

the pump'"'"'s performance and the patient'"'"'s physiology, the patient'"'"'s physiologic status comprising one or more of the following;

a drive unit input power for determination of pump flow rate;

a heart rate;

a pump flow rate; and

, a pressure differential; and

(iii) calculates a target flow based on the physiologic status; and

(iv) automatically adjusts the blood pump to the target flow.

2. The cardiac assist apparatus as set forth in claim 1, wherein the controller estimates a drive unit input power, a flow rate, a patient heart rate, pressure and the target flow rate.

3. The cardiac assist apparatus as set forth in claim 1, further comprising a drive unit winding commutation circuit for relaying the target flow to the drive unit motor.

4. The cardiac assist apparatus as set forth in claim 1, wherein the drive unit includes a brushless DC motor.

5. The cardiac assist apparatus as set forth in claim 1, wherein the power supply includes at least one rechargeable battery.

6. The cardiac assist apparatus as set forth in claim 1, wherein the frequency sensor includes one of a back EMF, Hall and optical sensor.

7. The cardiac assist apparatus as set forth in claim 1, wherein the patient'"'"'s physiological status is a heart rate, and the blood pump controller calculates the target pump flow rate based on the determined heart rate.

8. The cardiac assist apparatus as set forth in claim 7, wherein the target flow rate is within a pre-determined margin.

9. The cardiac assist apparatus as set forth in claim 8, wherein the margin comprises flow rates corresponding to preset maximum and minimum heartbeats per minute.

10. A method of controlling blood flow with a blood pump comprising the steps of:

sensing a current waveform of a drive motor of the blood pump;

sensing an input voltage waveform to the drive motor;

sensing a rotational frequency waveform of the drive motor;

passively determining, at a blood pump controller, a physiologic status of a patient based on one or more of the sensed current waveform, input voltage waveform, and rotational frequency waveform, the patient'"'"'s physiologic status comprising one or more of the following;

a drive motor input power of pump flow rate;

a heart;

a pump flow rate; and

, a pressure differential wherein

said step of determining is performed without affecting one or more of the following;

the pump'"'"'s performance and the patient'"'"'s physiology; and

calculating a target flow based on the physiologic status; and

automatically adjusting the blood pump to the target flow.

11. The method as set forth in claim 10, further comprising the step of analyzing the pump'"'"'s performance to verify that the pump is operating within predetermined conditions.

12. The method as set forth in claim 10, wherein the predetermined conditions comprise one or more of the following:

a minimum flow rate;

a maximum flow rate;

a minimum pulsatility;

a minimum pump rotational speed; and

, a maximum pump rotational speed.

13. The method as set forth in claim 12 wherein the predetermined conditions comprise one or more of the following:

absolute minimum flow rate, and relative minimum flow rate.

14. The method as set forth in claim 13 further comprising the step of calculating the relative minimum flow rate as Q_{rel min}=A*(ω

−

ω

₀)n wherein A, n and ω

₀ are constants and ω

is the pump rotational speed.

15. The method as set in claim 13, further comprising the step of reverting to a pre-selected default power level decrease in response to detecting ventricular suction.

16. The method as set forth in claim 10, wherein the motor input power is calculated using the equation:

S_elec=v*I

where S_elec=v*I is an average electrical power of the motor in a time interval T, v is the measured voltage, and I is an average current over the time interval I.

17. The method as set forth in claim 16, wherein the patient'"'"'s physiologic status is a heart rate, the step of calculating the heart rate comprises analyzing one or more of the following for a fundamental frequency:

the current waveform, input power, rotational frequency, pressure differential and pump flow waveform.

18. The method as set forth in claim 10, wherein the pump pressure differential P is calculated using the equation:

P_norm=ψ

(Q_norm)

where normalized pump pressure Pnorm=P/(σ

*ω

2), normalized flow rate Q_norm=Q/ω

, and ω

is the pump rotational speed, σ

is the blood density.

19. The method as set forth in claim 10, wherein the target pump flow is calculated using one of the following equations:

Q_target=C₁*HR+C₂; and

,

Q_target=f(M);

where Q_target is the desired flow rate, C₁ and C₂ are constants determined by patient heart condition and size, M=HR/P where P is the pressure and HR is the heart rate.

20. The method as set forth in claim 10, wherein the step of calculating the target pump flow further comprises the step of tracking the patient'"'"'s heart rate and basing the flow rate on the heart rate.

21. The method as set forth in claim 10, further comprising the step of reverting to a pre-selected default pump rotational speed in the event of a controller failure.

22. The method as set forth in claim 10, further comprising the step of reverting to a pre-selected default motor input power in the event of a controller failure.

23. The method as set forth in claim 10, further comprising the step of reverting to a pre-selected default PWM duty cycle in the event of a controller failure.

24. The method as set forth in claim 10, wherein the pump flow is calculated using the equation:

Q=φ

(S/ω

²)

where S=V*I, S is average electrical power, V is motor driven bus voltage, I is motor average current within a certain time interval, Q is pump flow, and ω

is the pump rotational speed.