Method for determination of analyte concentrations and related apparatus
First Claim
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1. A method for determining an analyte in a sample comprising the steps of:
- (a) introducing a sample to be evaluated into an electrochemical test strip having working and counter electrodes;
(b) applying a potential between the electrodes sufficient to generate a diffusion-limited current when analyte is present in the sample;
(c) dynamically determining a time, tpeak, as the time when diffusion limiting current at the counter electrode is established;
(d) sampling the current value at a time, Tmeas, wherein tmeas is after tpeak, and tmeas is determined based on the value of tpeak, and(e) generating an indication of analyte in the sample based on the sampled current value at time tmeas wherein tmeas is set to a1×
tpeak+a2 where a1 and a2 are empirically determined constants.
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Abstract
A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.
39 Citations
16 Claims
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1. A method for determining an analyte in a sample comprising the steps of:
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(a) introducing a sample to be evaluated into an electrochemical test strip having working and counter electrodes; (b) applying a potential between the electrodes sufficient to generate a diffusion-limited current when analyte is present in the sample; (c) dynamically determining a time, tpeak, as the time when diffusion limiting current at the counter electrode is established; (d) sampling the current value at a time, Tmeas, wherein tmeas is after tpeak, and tmeas is determined based on the value of tpeak, and (e) generating an indication of analyte in the sample based on the sampled current value at time tmeas wherein tmeas is set to a1×
tpeak+a2 where a1 and a2 are empirically determined constants.- View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A meter for receiving an electrochemical test strip having electrodes and providing a determination of an analyte in a sample applied to the electrochemical test strip when received in the meter, said meter comprising
(a) a housing having a slot for receiving an electrochemical test strip; -
(b) communications means for receiving input from and communicating a result to a user; (c) means for determining a time, tpeak, as the time when diffusion limiting current at the counter electrode is established and dynamically determining tmeas based upon the determined value of tpeak wherein tmeas is after tpeak, and tmeas is determined based on the value of tpeak; (d) means for evaluating current at tmeas to generate a determination of analyte wherein tmeas, is set to a1×
tpeak+a2 where a1 and a2 are empirically determined constants.- View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A measurement system comprising a meter and an electrochemical test strip received within the meter, wherein the meter is a meter for receiving an electrochemical test strip having electrodes and providing a determination of an analyte in a sample applied to the electrochemical test strip when received in the meter, said meter comprising
(a) a housing having a slot for receiving an electrochemical test strip; -
(b) communications means for receiving input from and communicating a result to a user; (c) means for determining a time, tpeak, as the time when diffusion limiting current at the counter electrode is established and dynamically determining tmeas based upon the determined value of tpeak wherein tmeas is after tpeak, and tmeas is determined based on the value of tpeak; (d) means for evaluating current at tmeas to generate a determination of analyte wherein tmeak, is set to a1×
tpeak+a2 where a1 and a2 are empirically determined constants.- View Dependent Claims (16)
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Specification