Composite dressing

• US 7,645,915 B2
• Filed: 12/11/2007
• Issued: 01/12/2010
• Est. Priority Date: 08/08/2007
• Status: Expired due to Fees

• Current Assignee: National Applied Research Laboratories (Government of The Republic of China), Taipei Medical University WAN Fan Hospital (Government of The Republic of China), Pharmaceutical Industry Technology and Development Center
• Original Assignee: National Applied Research Laboratories (Government of The Republic of China), Pharmaceutical Industry Technology and Development Center
• Inventors: Lin, Yung-Sheng, Huang, Ching-Cheng, Lai, Su-Huei, Leung, Ting-Kai
• Primary Examiner(s): Brown; Michael A.
• Application Number:
  US12/001,291
• Publication Number:
  US 20090043235A1
• Time in Patent Office: 763 Days
• Field of Search: 602 41- 59
• US Class Current: 602/42
• CPC Class Codes: A61F 13/0209 comprising superabsorbent material
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/022 having more than one layer with different fluid retention characteristics
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/22 containing macromolecular materials
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A composite dressing including a first polymeric layer, a second polymeric layer, a metal oxide, and a pharmaceutical active material is provided. The second polymeric layer is biocompatible and is disposed on a surface of the first polymeric layer. The metal oxide is distributed inside or on at least one surface of the first polymeric layer, while the pharmaceutical active material is distributed inside or on at least one surface of the second polymeric layer.

Claims

1. A composite dressing comprising:

a first polymeric layer;

a second polymeric layer disposed on at least one surface of the first polymeric layer; and

a metal oxide including a magnesium oxide and an iron oxide, and distributed in the first polymeric layer.

2. The composite dressing as claimed in claim 1 further comprising a pharmaceutical active material distributed in one selected from a group consisting of in the second polymeric layer, on at least one air contacting surface of the second polymeric layer and a combination thereof.

3. The composite dressing as claimed in claim 2 wherein the pharmaceutical active material is a non-steroid anti-inflammatory drug.

4. The composite dressing as claimed in claim 1 wherein the first polymeric layer is made by a cross-linking reaction and has a cross-linked structure.

5. The composite dressing as claimed in claim 1 wherein the first polymeric layer is made of a cross-linkable polymer containing an amine group.

6. The composite dressing as claimed in claim 1 wherein the first polymeric layer is made of at least one selected from a group consisting of polyurethane, polyester, polyethylene, polyimide, polyamide, polyamide-imide, chitosan, polysaccharide, polyvinylpyrrolidone, cellulose, polylactic acid, and polyether.

7. The composite dressing as claimed in claim 1 wherein the second polymeric layer is made by a cross-linking reaction and has a cross-linked structure.

8. The composite dressing as claimed in claim 1 wherein the second polymeric layer is bio compatible.

9. The composite dressing as claimed in claim 8 wherein the second polymeric layer is made of at least one selected from a group consisting of chitosan, sodium alginate, polysaccharide, polyvinylpyrrolidone, poly-2-hydroxyethyl methacrylate, polyvinyl alcohol, cellulose, hyaluronic acid, collagen, and polylactic acid.

10. The composite dressing as claimed in claim 1 wherein the second polymeric layer is made of a hydrogel.

11. The composite dressing as claimed in claim 1 wherein the first and the second polymeric layers are made of different materials.

12. The composite dressing as claimed in claim 1 wherein the first and the second polymeric layers are made of the same material.

13. The composite dressing as claimed in claim 1 wherein the first and the second polymeric layers are waterproof and moisture-permeable.

14. The composite dressing as claimed in claim 1 wherein the first and the second polymeric layers have elasticity and extensibility.

15. The composite dressing as claimed in claim 1 wherein the second polymeric layer is distributed on at least one surface of the first polymeric layer by a coating method.

16. The composite dressing as claimed in claim 1 wherein the second polymeric layer is distributed on at least one surface of the first polymeric layer by a dipping method.

17. The composite dressing as claimed in claim 1 wherein the metal oxide has a weight percentage of 0.1% to 40% relative to a total weight of the first polymeric layer and the metal oxide.

18. A composite dressing comprising:

a first polymeric layer;

a second polymeric layer strengthening the first polymeric layer, and encapsulating the first polymeric layer; and

a metal oxide distributed in one selected from a group consisting of in the first polymeric layer, on the at least one surface of the first polymeric layer and a combination thereof.

19. A composite dressing comprising:

a first polymeric layer;

a second polymeric layer disposed on at least one surface of the first polymeric layer;

a pharmaceutical active material being a non-steroid anti-inflammatory drug, and distributed in a manner selected from a group consisting of in the second polymeric layer, on at least one air contacting surface of the second polymeric layer and a combination thereof; and

a metal oxide distributed in one way selected from a group consisting of in the first polymeric layer, on the at least one surface of the first polymeric layer and a combination thereof.

20. The composite as claimed in claim 19, wherein the non-steroid anti-inflammatory drug includes indomethacin.