Cardiac contractility modulation device having anti-arrhythmic capabilities and method of operating thereof

• US 7,647,102 B2
• Filed: 11/18/2005
• Issued: 01/12/2010
• Est. Priority Date: 10/25/1999
• Status: Expired due to Fees

• Current Assignee: Impulse Dynamics NV
• Original Assignee: Impulse Dynamics NV
• Inventors: Darvish, Nissim, Belsky, Ziv, Prutchi, David, Routh, Andre G., Haluska, Edward
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/283,401
• Publication Number:
  US 20060212079A1
• Time in Patent Office: 1,516 Days
• Field of Search: 607 4- 28
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3904 External heart defibrillators [EHD]
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device (30) includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

Claims

1. A cardiac contractility modulating device comprising:

an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity of said heart and for delivering anti-arrhythmic therapy to said heart in response to detecting of said cardiac arrhythmia;

a cardiac contractility modulating unit configured for delivering cardiac contractility modulating signals to said heart for modulating the contractility of at least a portion of said heart, said cardiac contractility modulating unit is operatively connected to said anti-arrhythmic unit for providing said anti-arrhythmic therapy unit with first control signals associated with the delivery of said cardiac contractility modulating signals to said heart to prevent interference of said cardiac contractility modulating signals with said detecting of said cardiac arrhythmia by said anti-arrhythmic device;

a telemetry unit in communication with at least one of said anti-arrhythmic therapy unit and said cardiac contractility modulating unit, said telemetry unit is configured for telemetrically communicating with a telemetry transceiver; and

at least one power source for energizing said anti-arrhythmic therapy unit, said cardiac contractility modulating unit and said telemetry unit.

2. Apparatus according to claim 1, wherein said telemetry unit controls one of said anti-arrhythmic therapy unit and said cardiac contractility modulating unit.

3. Apparatus according to claim 1, wherein said telemetry unit controls both said anti-arrhythmic therapy unit and said cardiac contractility modulating unit.

4. Apparatus according to claim 1, wherein said anti-arrhythmic unit comprises a receiver for receiving control signals from said cardiac contractility modulating unit.

5. Apparatus according to claim 1, wherein said first control signals are directly delivered from said cardiac contractility modulating unit to said anti-arrhythmic therapy unit.

6. A cardiac contractility modulating device comprising:

an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity of said heart and for delivering anti-arrhythmic therapy to said heart in response to detecting of said cardiac arrhythmia;

a cardiac contractility modulating unit configured for delivering cardiac contractility modulating signals to said heart for modulating the contractility of at least a portion of said heart, said cardiac contractility modulating unit is operatively connected to said anti-arrhythmic unit for providing said anti-arrhythmic therapy unit with control signals associated with the delivery of said cardiac contractility modulating signals to said heart to prevent interference of said cardiac contractility modulating signals with said detecting of said cardiac arrhythmia by said anti-arrhythmic device;

and at least one power source for energizing said anti-arrhythmic therapy unit, said cardiac contractility modulating unit and a telemetry unit,

wherein said anti-arrhythmic therapy unit comprises a sensing unit for sensing said electrical signals and a detecting unit for detecting cardiac activity related events in said electrical signals, said sensing unit is configured for stopping the sensing of said electrical signals within a refractory time period in response to receiving one of said first control signals, and said detecting unit is configured for stopping said detecting of said cardiac activity related events within said refractory time period in response to receiving one of said control signals.

7. The device according to claim 6 wherein said refractory period begins before the application of a cardiac contractility modulating signal to the heart and ends after the application of said cardiac contractility modulating signal to the heart.

8. The device according to claim 6 wherein said cardiac contractility modulating unit is configured for varying the parameters of said cardiac contractility modulating signals in response to different detected cardiac conditions and to vary the parameters of said refractory period based on the parameters of the cardiac contractility modulating signal on a beat by beat basis.

9. A cardiac contractility modulating device comprising:

arrhythmia detection means configured for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity of said heart;

anti-arrhythmic therapy means for applying anti-arrhythmic therapy to said heart in response to detecting of said cardiac arrhythmia; and

cardiac contractility modulating means configured for delivering cardiac contractility modulating signals to said heart to modulate the contractility of at least a portion of said heart, said cardiac contractility modulating means being operatively connected to said arrhythmia detection means for providing said arrhythmia detection means with control signals associated with the delivery of said cardiac contractility modulating signals to said heart to prevent interference of said cardiac contractility modulating signals with the detecting of said cardiac arrhythmia by said arrhythmia detection means.

10. A cardiac contractility modulating device comprising:

an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity of said heart and for delivering anti-arrhythmic therapy to said heart in response to detecting of said cardiac arrhythmia, said anti-arrhythmic therapy unit is configured for disabling for a preset time period the delivery of cardiac contractility modulating signals to said heart when the heart rate of said patient exceeds a threshold value;

a cardiac contractility modulating unit configured for delivering cardiac contractility modulating signals to said heart for modulating the contractility of at least a portion of said heart, said cardiac contractility modulating unit is operatively connected to said anti-arrhythmic unit for providing said anti-arrhythmic therapy unit with first control signals associated with the delivery of said cardiac contractility modulating signals to said heart to prevent interference of said cardiac contractility modulating signals with said detecting of said cardiac arrhythmia by said anti-arrhythmic device; and

at least one power source for energizing said anti-arrhythmic therapy unit, said cardiac contractility modulating unit, and a telemetry unit.

11. A method for applying anti-arrhythmic therapy to a heart of a patient, the method comprising the steps of:

providing a cardiac contractility modulating device configured for applying cardiac contractility modulating signals to the heart of said patient;

sensing electrical signals associated with cardiac activity of said patient;

detecting in said electrical signals cardiac events associated with said cardiac activity for determining the heart rate of said patient;

disabling the delivery of cardiac contractility modulating signals to said heart when heart rate of said heart exceeds a threshold value to provide a cardiac contractility modulating signal free time period;

processing the data obtained during said cardiac contractility modulating signal free time period to detect a cardiac arrhythmia; and

delivering anti-arrhythmic therapy to the heart of said patient if an arrhythmia is detected.

12. The method according to claim 11 wherein said determining of said heart rate is based on determining the R-R intervals within said cardiac contractility modulating signal free time period.

13. The method according to claim 11 wherein said threshold value is determined from empirical data recorded in said patient.

14. The method according to claim 11 further including enabling the delivery of cardiac contractility modulating signals to said heart after terminating the delivering of said anti-arrhythmic therapy to said heart.

15. The method according to claim 11 wherein said processing comprises classifying the determined heart rate according to a classification method adapted to determine the suspected occurrence of different types of arrhythmias based on the determined heart rate, and controlling the delivery of a selected type of anti-arrhythmic therapy to said heart in response to detection of a suspected arrhythmia type.

16. The method according to claim 11 wherein said anti-arrhythmic therapy is selected from defibrillating shock therapy, cardioverting shock therapy, anti-tachycardia pacing therapy, anti-bradycardia pacing therapy, variable energy shock therapy, and combinations thereof.

17. The method according to claim 11 further including pacing at least one chamber of said heart of said patient.

18. The method according to claim 11 wherein said sensing is performed at one or more sites of said heart.