Syringe

• US 7,648,487 B2
• Filed: 09/28/2005
• Issued: 01/19/2010
• Est. Priority Date: 09/28/2004
• Status: Expired due to Fees

• Current Assignee: Nipro Corporation
• Original Assignee: Nipro Corporation
• Inventors: Ito, Akira, Nizuka, Takeshi, Kawamura, Shin-ich, Sutou, Dai, Murai, Yoshihisa
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Yeh; Jenner
• Application Number:
  US11/236,662
• Publication Number:
  US 20060200084A1
• Time in Patent Office: 1,574 Days
• Field of Search: 604/191, 604/230, 604/218, 604/187, 604/265, 604/12, 604/221, 523/210, 508/136, 508/208
• US Class Current: 604/230
• CPC Class Codes: A61M 2005/3131 specially adapted for improving sealing or sliding
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: C10M 169/06 Mixtures of thickeners and additives
• CPC Class Codes: C10M 2201/1056 used as thickening agents
• CPC Class Codes: C10M 2209/104 of alkylene oxides containing two carbon atoms only
• CPC Class Codes: C10M 2209/109 esterified
• CPC Class Codes: C10M 2229/02 Unspecified siloxanes; Silicones
• CPC Class Codes: C10M 2229/041 containing aliphatic substituents
• CPC Class Codes: C10M 2229/0415 used as base material
• CPC Class Codes: C10M 2229/042 containing aromatic substituents
• CPC Class Codes: C10M 2229/043 containing carbon-to-carbon double bonds
• CPC Class Codes: C10M 2229/044 containing silicon-to-hydrogen bonds
• CPC Class Codes: C10M 2229/046 containing silicon-oxygen-carbon bonds
• CPC Class Codes: C10N 2020/02 Viscosity; Viscosity index
• CPC Class Codes: C10N 2020/055 Particles related characteristics
• CPC Class Codes: C10N 2030/06 Oiliness; Film-strength; Anti-wear; Resistance to extreme pressure
• CPC Class Codes: C10N 2040/50 Medical uses

Abstract

A syringe coated with a lubricant containing a silicone oil and a fine silica powder on the inner surface of the barrel of the syringe can be used for injection of a surface-active drug solution without oil droplet formation on the inner surface while preventing an increase of the gasket sliding friction.

Claims

1. A syringe comprising:

a barrel,

a gasket contacting tightly with an inner surface of the barrel,

a plunger extending from the gasket to a rear end of the syringe for sliding the gasket in the barrel, the inner surface of the barrel being coated with a lubricant containing a straight silicone oil as a main component, a fine silica powder, and a nonionic surfactant, the lubricant containing 5 to 20% by weight of the fine silica powder and 0.1 to 15% by weight of the nonionic surfactant, and

the syringe being adapted to inject a drug solution containing a drug having a surface activity.

2. The syringe according to claim 1, wherein the silicone oil contained in the lubricant has a viscosity of 100 to 1,000,000 cst at 25°

C.

3. The syringe according to claim 1, wherein the fine silica powder contained in the lubricant has a specific surface area of 100 m2/g or more.

4. The syringe according to claim 1, wherein the nonionic surfactant comprises at least one agent selected from the group consisting of polyoxyethylene higher alcohol ethers, polyoxyethylene alkyl phenyl ethers, sorbitan alkylates, polyoxyethylene sorbitan alkylates, glycerolalkylates, polyoxyethylene hardened caster oils, and silicone-based nonionic surfactants having hydrophilic substituents.

5. The syringe according to claim 4, wherein the nonionic surfactant comprises at least one agent selected from the group consisting of polyoxyethylene sorbitan monooleate, polyoxyethylene hardened caster oils, and polyether-modified silicones.

6. A prefilled syringe comprising:

a barrel,

a gasket contacting tightly with an inner surface of the barrel,

a plunger extending from the gasket to a rear end of the syringe for sliding the gasket in the barrel, the inner surface of the barrel being coated with a lubricant containing a straight silicone oil as a main component, a fine silica powder, and a nonionic surfactant, the lubricant containing 5 to 20% by weight of the fine silica powder and 0.1 to 15% by weight of the nonionic surfactant, and

the syringe being filled with a drug solution containing a drug having a surface activity.

7. The syringe according to claim 6, wherein the drug having a surface activity has a surface tension of 70 mN/m or less.

8. The syringe according to claim 7, wherein the drug having a surface activity comprises at least one agent selected from the group consisting of hyaluronate salts, glycyrrhizinate salts, polyoxyethylene sorbitan esters, polyethylene glycol, polyoxyethylene castor oil, polypropylene glycol, lecithin, arid glycerin.