Device and method for accurate delivery of an active agent
First Claim
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1. An implantable device for accurate delivery of an active agent, said device comprising:
- the active agent;
a housing (2) including a reservoir (3) that contains the active agent;
a valving and control mechanism (10) fitted at least partially within said housing (2) and fitted at least partially between the reservoir and an opening to an environment of use, wherein the valving and control mechanism comprises a valve seat member (12) peripherally sealed with respect to said reservoir and a plunger (18) adapted to slide with respect to said valve seat member (12) and said valving and control mechanism (10) is able to withstand pressure buildup in the reservoir during temperature and atmospheric pressure cycling during storage and capable of assuming an open configuration and a closed configuration, said valving and control mechanism (10) closes off said reservoir (3) when in said closed configuration, thereby preventing leakage of the active agent during storage in said device; and
further wherein said valving and control mechanism (10) opens said reservoir (3) to a flow path when in said open configuration, thereby permitting controlled delivery of the active agent.
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Abstract
Implantable delivery devices (1) for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir (3) for storing the agent, a driving means for driving the agent from the reservoir (3) and a valving and control mechanism (10) which is positively actuatable between a closed configuration and an open configuration.
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Citations
26 Claims
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1. An implantable device for accurate delivery of an active agent, said device comprising:
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the active agent; a housing (2) including a reservoir (3) that contains the active agent; a valving and control mechanism (10) fitted at least partially within said housing (2) and fitted at least partially between the reservoir and an opening to an environment of use, wherein the valving and control mechanism comprises a valve seat member (12) peripherally sealed with respect to said reservoir and a plunger (18) adapted to slide with respect to said valve seat member (12) and said valving and control mechanism (10) is able to withstand pressure buildup in the reservoir during temperature and atmospheric pressure cycling during storage and capable of assuming an open configuration and a closed configuration, said valving and control mechanism (10) closes off said reservoir (3) when in said closed configuration, thereby preventing leakage of the active agent during storage in said device; and
further wherein said valving and control mechanism (10) opens said reservoir (3) to a flow path when in said open configuration, thereby permitting controlled delivery of the active agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification