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Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels

  • US 7,648,713 B2
  • Filed: 07/09/2003
  • Issued: 01/19/2010
  • Est. Priority Date: 08/14/1998
  • Status: Expired due to Fees
First Claim
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1. A medical implant to seal a lumen or void in a body of a patient comprising:

  • a sterilized pharmaceutically acceptable covalently crosslinked hydrogel polymerized from at least one synthetic hydrophilic polyethylene glycol macromer,the hydrogel having a substantially less than equilibrium level of hydration for undergoing a volumetric expansion of at least about 50% after swelling with physiological fluid andhaving a size and a swellability to press against tissue surrounding the lumen or void upon swelling to seal and thereby occlude the lumen or void upon swelling from exposure to a fluid from the body,wherein the hydrogel, at the substantially less than equilibrium level of hydration, has a shape selected from the group consisting of a rod and a sheet rolled from one edge to another to form a roll, with the rod or roll outer diameter being no more than 1.5 mm.

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