19-nor-vitamin D analogs with 3,2-dihydrofuran ring
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Abstract
19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 3β-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit selective in vitro and in vivo activities, making them therapeutic agents for the treatment or prophylaxis of autoimmune diseases, some types of cancers, metabolic bone diseases, osteomalacia, osteopenia, secondary hyperparathyroidism, psoriasis, or other skin diseases.
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Citations
103 Claims
- 1. A compound having the formula:
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6. 3,2-dihydrofuran-1α
- ,25-dihydroxy-19-nor-vitamin D3 having the formula;
- ,25-dihydroxy-19-nor-vitamin D3 having the formula;
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7. A pharmaceutical composition containing an effective amount of 3,2-dihydrofuran-1α
- ,25-dihydroxy-19-nor-vitamin D3 together with a pharmaceutically acceptable excipient.
- View Dependent Claims (8, 9)
- 10. A method of treating psoriasis comprising administering to a subject with psoriasis an effective amount of a compound having the formula:
- 20. A method of treating a disease selected from the group consisting of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 29. A method of treating an autoimmune disease selected from the group consisting of multiple sclerosis, lupus, diabetes mellitus, host versus graft rejection, and rejection of organ transplants, comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 38. A method of treating an inflammatory disease selected from the group consisting of rheumatoid arthritis, asthma, and inflammatory bowel diseases, comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 47. A method of treating a skin condition selected from the group consisting of wrinkles, lack of adequate skin firmness, lack of adequate dermal hydration and insufficient sebum secretion which comprises administering to a subject with said skin condition an effective amount of a compound having the formula:
- 57. A method of treating renal osteodystrophy comprising administering to a subject with renal osteodystrophy an effective amount of a compound having the formula:
- 66. A method of treating obesity of an animal, inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal comprising administering to an animal in need thereof an effective amount of a compound having the formula:
- 78. A method of treating a metabolic bone disease comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 92. A method of treating osteopenia comprising administering to a subject with osteopenia an effective amount of a compound having the formula:
- 101. A compound having the formula:
Specification