Synthesis of epothilones, intermediates thereto and analogues thereof

• US 7,649,006 B2
• Filed: 05/09/2003
• Issued: 01/19/2010
• Est. Priority Date: 08/23/2002
• Status: Expired due to Fees

• Current Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Original Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Inventors: Gabarda, Ana E., Dong, Huajin, Fumikiko, Yoshimura, Danishefsky, Samuel J., Chou, Ting-Chao, Rivkin, Alexey
• Primary Examiner(s): Saeed; Kamal A
• Application Number:
  US10/435,408
• Publication Number:
  US 20040053910A1
• Time in Patent Office: 2,447 Days
• Field of Search: 514/365, 514/374, 548/203, 548/205, 548/235
• US Class Current: 514/365
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 313/00 Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
• CPC Class Codes: C07D 413/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 417/02 containing two hetero rings
• CPC Class Codes: C07D 417/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 493/04 Ortho-condensed systems

Abstract

The present invention provides compounds of formula (I):

• • as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

Claims

1. A compound of the formula:

2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.

3. The pharmaceutical composition of claim 2 further comprising CREMOPHOR (polyoxyethylated castor oil).

4. The pharmaceutical composition of claim 2 further comprising CREMOPHOR (polyoxyethylated castor oil) and ethanol.

5. The pharmaceutical composition of claim 2 further comprising an additional cytotoxic agent.