Microneedle transport device
First Claim
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1. A transdermal transport device, comprising:
- a reservoir including at least two reservoir chambers, a first reservoir chamber including a sensor for detecting concentration of a substance and a second reservoir chamber for holding a formulation of an active principle;
an array of needles, each needle having a bore in fluid communication with the reservoir;
a first actuator that drives the array of needles into a body, the first actuator being reversible to withdraw the needles from the body; and
a second actuator that withdraws a fluid from the body through the needles into the first reservoir chamber;
the second actuator being reversible to deliver the formulation of the active principle from the second reservoir chamber to the body in response to detected concentration of the substance in the withdrawn fluid.
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Abstract
A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
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Citations
23 Claims
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1. A transdermal transport device, comprising:
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a reservoir including at least two reservoir chambers, a first reservoir chamber including a sensor for detecting concentration of a substance and a second reservoir chamber for holding a formulation of an active principle; an array of needles, each needle having a bore in fluid communication with the reservoir; a first actuator that drives the array of needles into a body, the first actuator being reversible to withdraw the needles from the body; and a second actuator that withdraws a fluid from the body through the needles into the first reservoir chamber;
the second actuator being reversible to deliver the formulation of the active principle from the second reservoir chamber to the body in response to detected concentration of the substance in the withdrawn fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for transporting a formulation of an active principle through a surface of a body, the method comprising:
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advancing an array of needles into the body, each needle having a bore in fluid communication with a reservoir, the reservoir including at least two reservoir chambers, a first reservoir chamber including a sensor for detecting concentration of a substance and a second reservoir chamber for holding a formulation of an active principle; withdrawing a fluid from the body into the first reservoir chamber; detecting the concentration of the substance in the withdrawn fluid using the sensor in the first reservoir chamber; and in response to detected concentration of the substance in the withdrawn fluid, pumping the formulation of the active principle from the second reservoir chamber into the body using the second actuator. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification