Cellulosic-based interference domain for an analyte sensor
First Claim
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1. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
- at least one electroactive surface; and
a membrane system disposed on the electroactive surface, wherein the membrane system comprises;
an electrode domain comprising a hydrophilic polymer;
an interference domain disposed more distally from the electroactive surface than the electrode domain and comprising cellulose acetate and cellulose acetate butyrate, wherein the interference domain is configured to resist passage therethrough of at least one interferent, and wherein an equivalent glucose signal response of the at least one interferent is less than about 30 mg/dL;
an enzyme domain disposed more distally from the electroactive surface than the interference domain; and
a resistance domain disposed more distally from the electroactive surface than the enzyme domain, the resistance domain comprising a semipermeable membrane that controls a flux of oxygen and glucose to the underlying enzyme domain.
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Abstract
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.
910 Citations
55 Claims
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1. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
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at least one electroactive surface; and a membrane system disposed on the electroactive surface, wherein the membrane system comprises; an electrode domain comprising a hydrophilic polymer; an interference domain disposed more distally from the electroactive surface than the electrode domain and comprising cellulose acetate and cellulose acetate butyrate, wherein the interference domain is configured to resist passage therethrough of at least one interferent, and wherein an equivalent glucose signal response of the at least one interferent is less than about 30 mg/dL; an enzyme domain disposed more distally from the electroactive surface than the interference domain; and a resistance domain disposed more distally from the electroactive surface than the enzyme domain, the resistance domain comprising a semipermeable membrane that controls a flux of oxygen and glucose to the underlying enzyme domain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for forming an electrochemical sensor for measuring an analyte in a host, the method comprising the steps of:
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providing at least one electroactive surface; forming a membrane system on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative and a photoinitiator, wherein the interference domain is configured to resist passage therethrough of interfering species while permitting diffusion therethrough of a measurable species; and exposing the interference domain to visible light sufficient for substantially crosslinking the interference domain to create covalent bonds but without destroying, delaminating, or significantly breaking down the membrane system and without significantly damaging the at least one electroactive surface, whereby an electrochemical sensor is obtained. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A glucose sensor configured for insertion into a host for measuring an analyte in the host, the sensor comprising:
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a first working electrode having a first electroactive surface located under a first portion of a membrane system comprising an enzyme, wherein the first working electrode is configured to measure a first signal; and a second working electrode having a second electroactive surface located under a second portion of the membrane system comprising an inactive-enzymatic or a non-enzymatic portion, wherein the second working electrode is configured to measure a baseline signal, wherein the baseline signal is subtracted from the first signal to produce a glucose signal substantially without a baseline component, and wherein the membrane system comprises an interference domain located over both the first and second electroactive surfaces, wherein the interference domain comprises at least one cellulosic derivative configured to substantially restrict, resist, or block a passage of at least one interferent through the interference domain. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method for forming an electrochemical sensor for measuring an analyte in a host, the method comprising the steps of:
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providing at least one electroactive surface; forming a membrane system on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of interfering species while permitting diffusion therethrough of a measurable species; and exposing the interference domain to ultraviolet light sufficient for substantially crosslinking the interference domain to create covalent bonds but without destroying, delaminating, or significantly breaking down the membrane system and without significantly damaging the at least one electroactive surface, whereby an electrochemical sensor is obtained. - View Dependent Claims (52, 53, 54, 55)
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Specification