Medical devices with broad spectrum antimicrobial activity

• US 7,651,661 B2
• Filed: 10/19/2007
• Issued: 01/26/2010
• Est. Priority Date: 01/12/2001
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Raad, Issam, Nabulsi, Nabeel, Hanna, Hend A.
• Primary Examiner(s): McKane; Elizabeth L
• Application Number:
  US11/875,699
• Publication Number:
  US 20080183152A1
• Time in Patent Office: 830 Days
• Field of Search: None
• US Class Current: 422/28
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/12 Bis-chlorophenols
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 33/06 Nitrogen directly attached to an aromatic ring system
• CPC Class Codes: A01N 33/26 containing nitrogen-to-nitrogen bonds, e.g. azides, diazo-amino compounds, diazonium compounds, hydrazine derivatives
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 43/38 condensed with carbocyclic rings
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A01N 43/42 condensed with carbocyclic rings
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61L 2/16 using chemical substances
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C02F 1/50 : by addition or application of a germicide or by oligodynamic treatment C02F1/4606, C02F1/467, C02F1/76 take precedence

Abstract

The present invention provides novel broad spectrum antiseptic compounds that further have properties that allow them to be coated/impregnated into polymer surfaces. Methods for coating these antiseptic compounds onto medical devices especially indwelling medical devices to prevent the growth of pathogens in such devices and hence, to prevent infection to patients via such devices are provided. The invention also provides antiseptics that are useful as general surface disinfectants and sterilizers, fluid disinfectants and biocide preservatives.

Claims

1. A medical device coated or impregnated with a composition comprising chlorhexidine and a dye selected from the group consisting of gentian violet and brilliant green, wherein the medical device is selected from the group consisting of an endotracheal tube, a vascular catheter, a nephrostomy tube, a stent, an orthopedic device, a prosthetic valve, a urinary catheter, a peritoneal catheter, an epidural catheter, a central nervous system catheter, a blood exchanging device, a vascular access port, an extracorporeal circuit, a vascular graft, a pump, a glove, a table, and a medical implant.

2. The medical device of claim 1, wherein said central nervous system catheter is a intraventricular shunt.

3. The medical device of claim 1, wherein the dye is gentian violet.

4. The medical device of claim 1, wherein the stent is a biliary stent.

5. The medical device of claim 1, wherein the dye is brilliant green.

6. The medical device of claim 1 wherein the medical device is an endotracheal tube.

7. The medical device of claim 1, wherein the medical device is a vascular catheter.

8. The medical device of claim 7, wherein the dye is gentian violet.

9. The medical device of claim 7, wherein the dye is brilliant green.

10. The medical device of claim 1, wherein the medical device is a nephrostomy tube.

11. The medical device of claim 1, wherein the medical device is an orthopedic device.

12. The medical device of claim 1, wherein the medical device is a prosthetic valve.

13. The medical device of claim 1, wherein the medical device is a urinary catheter.

14. The medical device of claim 1, wherein the medical device is a peritoneal catheter.

15. The medical device of claim 1, wherein the medical device is an epidural catheter.

16. The medical device of claim 1, wherein the medical device is a central nervous system catheter.

17. The medical device of claim 1, wherein the medical device is a blood exchanging device.

18. The medical device of claim 1, wherein the medical device is a vascular access port.

19. The medical device of claim 1, wherein the medical device is an extracorporeal circuit.

20. The medical device of claim 1, wherein the medical device is a vascular graft.

21. The medical device of claim 1, wherein the medical device is a glove.

22. The medical device of claim 1, wherein the medical device is a pump.

23. The medical device of claim 1, wherein the medical device is a table.

24. The medical device of claim 1, wherein the medical device is a medical implant.

25. The medical device of claim 1, wherein the medical device is composed of a polymer.

26. The medical device of claim 25, wherein the polymer is polyurethane.

27. The medical device of claim 25, wherein the polymer is silicone.

28. A method for preventing nosocomial infections in a subject comprising coating or impregnating a medical device that the subject is required to use with a composition comprising chlorhexidine and a dye selected from the group consisting of gentian violet and brilliant green, wherein the medical device is selected from the group consisting of an endotracheal tube, a vascular catheter, a nephrostomy tube, a stent, an orthopedic device, a prosthetic valve, a urinary catheter, a peritoneal catheter, an epidural catheter, a central nervous system catheter, a blood exchanging device, a vascular access port, an extracorporeal circuit, a vascular graft, a pump, a glove, a table, and a medical implant.

29. The method of claim 28, wherein said subject is human.

30. The method of claim 28, wherein said nosocomial infection is pneumonia, bacteremia, fungimia, candidemia, a urinary tract infection, a catheter-exit site infection, and a surgical wound infection.

31. The method of claim 28, wherein said nosocomial infection is caused by a bacterium.

32. The method of claim 31, wherein said bacterium is a resistant bacterium.

33. The method of claim 32, wherein said resistant bacterium is selected from a group comprising methicillin-resistant staphylococci, vancomycin-resistant enterococci, and resistant Pseudomonas aeruginosa.

34. The method of claim 28, wherein said nosocomial infection is caused by a fungus.

35. The method of claim 34, wherein said fungus is a resistant fungus.

36. The method of claim 35, wherein said resistant fungus belongs to Candida species.

37. The method of claim 28, wherein the dye is gentian violet.

38. An article comprising a glove coated or impregnated with a composition comprising brilliant green and chlorhexidine.