Polymerizable emulsions for tissue engineering
First Claim
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1. A biocompatible, non toxic, viscoelastic material for tissue engineering having two discrete organic and aqueous phases comprising a polymerized emulsion having:
- a) a continuous hydrophobic organic phase comprised of polymerized ethylenically unsaturated acrylate monomers; and
b) a discontinuous aqueous phase comprising water;
wherein the viscoelastic material is prepared by polymerization of ethylenically unsaturated acrylate monomers in an inverse (“
water-in-oil”
) fluid emulsion, said fluid emulsion also comprising two distinct phases,wherein the aqueous phase is present in the fluid emulsion in an amount of about 0.5% to about 90% weight/weight of the organic phase.
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Abstract
Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
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Citations
29 Claims
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1. A biocompatible, non toxic, viscoelastic material for tissue engineering having two discrete organic and aqueous phases comprising a polymerized emulsion having:
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a) a continuous hydrophobic organic phase comprised of polymerized ethylenically unsaturated acrylate monomers; and b) a discontinuous aqueous phase comprising water; wherein the viscoelastic material is prepared by polymerization of ethylenically unsaturated acrylate monomers in an inverse (“
water-in-oil”
) fluid emulsion, said fluid emulsion also comprising two distinct phases,wherein the aqueous phase is present in the fluid emulsion in an amount of about 0.5% to about 90% weight/weight of the organic phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 26, 27, 28, 29)
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23. A biocompatible, non toxic, inverse (“
- water-in-oil”
) fluid emulsion for tissue engineering, comprising two discrete phases;a continuous hydrophobic organic phase comprising lauryl acrylate, bisacyl phosphine oxide, bisphenol A diglycidylether, and an inert glass filler, and a discontinuous aqueous phase comprising water, wherein the aqueous phase is a solution that contains about 1% hydroxypropyl methyl cellulose and is present in an amount of about 5% weight/weight of the organic phase, which when the fluid emulsion is polymerized in situ, forms a solid viscoelastic material comprising; a) a continuous hydrophobic organic phase comprised of polymerized ethylenically unsaturated acrylate monomers; and b) a discontinuous aqueous (“
water”
) phase comprising water.
- water-in-oil”
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24. A kit for tissue engineering comprising a dual component cartridge having first and second individual compartments, wherein
the first compartment contains (i) benzoyl peroxide and (ii) a biocompatible, non toxic, inverse (“ - water-in-oil”
) fluid emulsion for tissue engineering, comprising two discrete phases;
a continuous hydrophobic organic phase comprising lauryl acrylate, bisphenol A diglycidylether, and an inert glass filler, and a discontinuous aqueous phase comprising water, wherein the aqueous phase is a solution that contains about 1% hydroxypropyl methyl cellulose and is present in an amount of about 5% weight/weight of the organic phase,the second compartment contains (i) a tertiary amine and (ii) a biocompatible, non toxic, inverse (“
water-in-oil”
) fluid emulsion for tissue engineering, comprising two discrete phases;
a continuous hydrophobic organic phase comprising lauryl acrylate, bisphenol A diglycidylether, and an inert glass filler, and a discontinuous aqueous phase comprising water, wherein the aqueous phase is a solution that contains about 1% hydroxypropyl methyl cellulose and is present in an amount of about 5% weight/weight of the organic phase, andwhen the contents of the first and second compartments are combined, the emulsion polymerizes in situ to form a solid viscoelastic material comprising; a) a continuous hydrophobic organic phase comprised of polymerized ethylenically unsaturated acrylate monomers; and b) a discontinuous aqueous (“
water”
) phase. - View Dependent Claims (25)
- water-in-oil”
Specification