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Polymerizable emulsions for tissue engineering

  • US 7,651,683 B2
  • Filed: 05/01/2007
  • Issued: 01/26/2010
  • Est. Priority Date: 10/29/2003
  • Status: Expired due to Fees
First Claim
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1. A method of preparing a nontoxic, viscoelastic material for tissue engineering, wherein the viscoelastic material comprises a polymerized emulsion having two discrete organic and aqueous phases, the method comprising:

  • a) preparing a nontoxic, inverse (“

    water-in-oil”

    ) fluid emulsion comprising two discrete phases;

    i) a continuous hydrophobic organic (“

    oil”

    ) phase, comprising one or more reactive, ethylenically unsaturated, polymerizable acrylate monomers, and at least one activator- controlled polymerization initiator; and

    ii) a discontinuous aqueous (“

    water”

    ) phase comprising water,wherein the aqueous phase is present in the emulsion in an amount of about 0.5% to about 90% weight/weight of the organic phase; and

    b) polymerizing the fluid emulsion in situ to form the viscoelastic material, wherein the viscoelastic material comprises;

    i) a continuous hydrophobic organic phase comprised of polymerized ethylenically unsaturated acrylate monomers;

    ii) a discontinuous aqueous (“

    water”

    ) phase comprising water.

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